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nono-1 NONO (conserved nuclear protein, aka PSF) homolog;NOPS domain-containing protein;RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175844, updated on 22-Sep-2022

Summary

Gene symbol
nono-1
Gene description
NONO (conserved nuclear protein, aka PSF) homolog;NOPS domain-containing protein;RRM domain-containing protein
Primary source
WormBase:WBGene00017778
Locus tag
CELE_F25B5.7
See related
AllianceGenome:WB:WBGene00017778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleus. Is expressed in body wall musculature and reproductive system. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding); PSPC1 (paraspeckle component 1); and SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See nono-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (5953557..5958246, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative folylpolyglutamate synthase Neighboring gene 5'-nucleotidase;Putative cytosolic 5'-nucleotidase 3;Uncharacterized protein Neighboring gene Pseudocleavage protein nop-1 Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NONO (conserved nuclear protein, aka PSF) homolog;NOPS domain-containing protein;RRM domain-containing protein
NP_001359971.1
  • Confirmed by transcript evidence
NP_001379859.1
  • Confirmed by transcript evidence
NP_498295.3
  • Product from WormBase gene class nono;
    Confirmed by transcript evidence
NP_871666.1
  • Product from WormBase gene class nono;
    Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5953557..5958246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065894.5NP_498295.3  NONO (conserved nuclear protein, aka PSF) homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498295.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3GWA1
    Conserved Domains (3) summary
    cd12931
    Location:260349
    eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family
    cd12332
    Location:115184
    RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
    cd12333
    Location:190269
    RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
  2. NM_001372604.3NP_001359971.1  NOPS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3GWA0
    Conserved Domains (1) summary
    cl06904
    Location:169
    eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family
  3. NM_001392114.1NP_001379859.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QI9
    Conserved Domains (2) summary
    PRK10811
    Location:245
    rne; ribonuclease E; Reviewed
    cl17169
    Location:115157
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. NM_181937.5NP_871666.1  NONO (conserved nuclear protein, aka PSF) homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7K5
    Conserved Domains (3) summary
    cd12931
    Location:260349
    eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family
    cd12332
    Location:115184
    RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
    cd12333
    Location:190269
    RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family