U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

polq-1 DNA polymerase theta [ Caenorhabditis elegans ]

Gene ID: 175810, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
polq-1
Gene description
DNA polymerase theta
Primary source
WormBase:WBGene00020964
Locus tag
CELE_W03A3.2
See related
AllianceGenome:WB:WBGene00020964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-directed DNA polymerase activity. Involved in base-excision repair, gap-filling and cellular response to ionizing radiation. Predicted to be located in nucleus. Orthologous to human POLQ (DNA polymerase theta). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: III
Exon count:
19
Sequence:
Chromosome: III; NC_003281.10 (5791119..5803160, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DNA polymerase Neighboring gene SLC (SoLute Carrier) homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-10 Neighboring gene Kinetochore protein Nuf2 homolog Neighboring gene Ras-associating domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining. van Schendel R, et al. PLoS Genet, 2016 Oct. PMID 27755535, Free PMC Article
  2. Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis. van Schendel R, et al. Nat Commun, 2015 Jun 16. PMID 26077599, Free PMC Article
  3. Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Asagoshi K, et al. Nucleic Acids Res, 2012 Jan. PMID 21917855, Free PMC Article
  4. BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining. Kamp JA, et al. Nat Commun, 2020 Jul 17. PMID 32680986, Free PMC Article
  5. Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes. Harris PV, et al. Mol Cell Biol, 1996 Oct. PMID 8816490, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans.
    Title: Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans.
  2. BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
    Title: BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
  3. Our study provides a step-wise and versatile model for the in vivo mechanism of POLQ action, which explains the molecular nature of mutagen-induced deletion alleles
    Title: Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining.
  4. POLQ is a major driver of inheritable genomic alterations in Caenorhabditis elegans.
    Title: Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis.
  5. non-canonical DNA break repair mechanism generates deletions characterized by an extremely narrow size distribution
    Title: A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair, gap-filling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to ionizing radiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DNA polymerase theta
NP_001367994.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5791119..5803160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379729.2 → NP_001367994.1  DNA polymerase theta [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0FLQ6, G4SPM6
    Conserved Domains (2) summary
    cd08638
    Location:1230 → 1602
    DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
    COG1204
    Location:12 → 696
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous