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ida-1 Receptor-type tyrosine-protein phosphatase-like ida-1 [ Caenorhabditis elegans ]

Gene ID: 175807, updated on 22-Sep-2022

Summary

Gene symbol
ida-1
Gene description
Receptor-type tyrosine-protein phosphatase-like ida-1
Primary source
WormBase:WBGene00002048
Locus tag
CELE_B0244.2
See related
AllianceGenome:WB:WBGene00002048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Involved in positive regulation of anterior/posterior axon guidance; positive regulation of neurotransmitter secretion; and ventral cord development. Located in dense core granule and synapse. Is expressed in several structures, including buccal cavity; egg-laying apparatus; neurons; preanal ganglion; and somatic nervous system. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N) and PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ida-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (5755539..5765816)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein;Putative G-protein coupled receptor B0244.4 Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene CUTiclin-Like Neighboring gene DNA polymerase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in exocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of anterior/posterior axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ventral cord development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network transport vesicle TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Receptor-type tyrosine-protein phosphatase-like ida-1
NP_498245.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5755539..5765816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065844.7NP_498245.2  Receptor-type tyrosine-protein phosphatase-like ida-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498245.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGJ5
    UniProtKB/TrEMBL
    G5EGJ5
    Conserved Domains (1) summary
    cd00047
    Location:529755
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...