hap-1 Inosine triphosphate pyrophosphatase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hap-1
Official Full Name: Inosine triphosphate pyrophosphatase
Primary source: WormBase:WBGene00001823
Locus tag: CELE_ZC395.7
See related: AllianceGenome:WB:WBGene00001823
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nucleoside triphosphate diphosphatase activity. Predicted to be involved in nucleoside triphosphate catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); developmental and epileptic encephalopathy 35; hepatitis C; rheumatoid arthritis; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See hap-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (5263943..5264996)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC395.7 (e-PCR)
- UniSTS:317763

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ITP diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ITP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables XTP diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables XTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables dITP diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dITP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in deoxyribonucleoside triphosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleoside triphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Inosine triphosphate pyrophosphatase

NP_498121.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5263943..5264996

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065720.4 → NP_498121.1 Inosine triphosphate pyrophosphatase

See identical proteins and their annotated locations for NP_498121.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GYG4

Conserved Domains (1) summary

cd00515
Location:6 → 180

HAM1; NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A ...