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mpk-1 Mitogen-activated protein kinase mpk-1 [ Caenorhabditis elegans ]

Gene ID: 175545, updated on 5-Sep-2019

Summary

Gene symbol
mpk-1
Gene description
Mitogen-activated protein kinase mpk-1
Primary source
WormBase:WBGene00003401
Locus tag
CELE_F43C1.2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See mpk-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (4216759..4228108, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Protein phosphatase PHLPP-like protein Neighboring gene hypothetical protein Neighboring gene Nuclear hormone receptor family member nhr-20 Neighboring gene NFACT-R_1 domain-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the mpk-1 gene: The mpk-1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oogenesis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vulval development IGI
Inferred from Genetic Interaction
more info
PubMed 
vulval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Mitogen-activated protein kinase mpk-1
NP_001022583.1
  • Confirmed by transcript evidence
NP_001022584.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4216759..4228108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027412.4NP_001022583.1  Mitogen-activated protein kinase mpk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39745
    Conserved Domains (2) summary
    smart00220
    Location:28316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07849
    Location:22354
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  2. NM_001027413.3NP_001022584.1  Mitogen-activated protein kinase mpk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022584.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39745
    Conserved Domains (2) summary
    smart00220
    Location:96384
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07849
    Location:90422
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
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