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DMBT1 deleted in malignant brain tumors 1 [ Homo sapiens (human) ]

Gene ID: 1755, updated on 12-Aug-2022

Summary

Official Symbol
DMBT1provided by HGNC
Official Full Name
deleted in malignant brain tumors 1provided by HGNC
Primary source
HGNC:HGNC:2926
See related
Ensembl:ENSG00000187908 MIM:601969; AllianceGenome:HGNC:2926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAG; GP340; SALSA; muclin
Summary
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]
Expression
Biased expression in duodenum (RPKM 482.0), small intestine (RPKM 157.2) and 1 other tissue See more
Orthologs
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Genomic context

See DMBT1 in Genome Data Viewer
Location:
10q26.13
Exon count:
56
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (122560754..122643736)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (123456615..123518779)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124320270..124403252)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378525 Neighboring gene age-related maculopathy susceptibility 2 Neighboring gene HtrA serine peptidase 1 Neighboring gene Sharpr-MPRA regulatory region 5374 Neighboring gene carbohydrate-binding protein AQN-1-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Aalanine substitution scan reveals amino acids D34, D35, N96, and E101 in gp340 are the critical residues interaction with HIV-1 gp120 PubMed
env HIV-1 gp120 binds peptides (residues 21-40, 66-85, and 91-109) derived from the first scavenger receptor cysteine rich domain (SRCR1) of gp340 with relative high affinity binding activity PubMed
env A 35KDa purified recombinant N-terminal protein of gp340 (SAG) interacts with the V3 domain of HIV-1 gp120 PubMed
env The interaction of gp340 (SAG) with HIV-1 gp120 is enhanced by prebinding of sCD4 to gp120, suggesting that gp340 inhibitory activity is mediated by blocking access of gp120 to its chemokine coreceptor PubMed
env Salivary agglutinin (SAG), a high molecular weight glycoprotein (340 kDa), binds to HIV-1 gp120; SAG binding to gp120 is Ca(2+) dependent and specifically inhibits HIV-1 infectivity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ61058, MGC164738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-dependent protein binding TAS
Traceable Author Statement
more info
PubMed 
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pattern recognition receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables zymogen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of bacterial lipoprotein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in epithelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in induction of bacterial agglutination TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
deleted in malignant brain tumors 1 protein
Names
glycoprotein 340
hensin
salivary agglutinin
salivary scavenger and agglutinin
surfactant pulmonary-associated D-binding protein
vomeroglandin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012644.1 RefSeqGene

    Range
    5001..88072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320644.2NP_001307573.1  deleted in malignant brain tumors 1 protein isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AJ243212, AJ297935, AL603764, BX640988
    UniProtKB/Swiss-Prot
    Q9UGM3
    UniProtKB/TrEMBL
    A0A590UJ76
    Conserved Domains (6) summary
    smart00042
    Location:17751874
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21262378
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20072115
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22322378
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  2. NM_001377530.1NP_001364459.1  deleted in malignant brain tumors 1 protein isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AL603764
    Related
    ENSP00000342210.4, ENST00000338354.10
  3. NM_004406.3NP_004397.2  deleted in malignant brain tumors 1 protein isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AL603764
    Consensus CDS
    CCDS44491.1
    UniProtKB/Swiss-Prot
    Q9UGM3
    Related
    ENSP00000357952.2, ENST00000368956.6
    Conserved Domains (5) summary
    smart00202
    Location:494594
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:14991751
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:11381248
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:16051751
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:499594
    SRCR; Scavenger receptor cysteine-rich domain
  4. NM_007329.3NP_015568.2  deleted in malignant brain tumors 1 protein isoform b precursor

    See identical proteins and their annotated locations for NP_015568.2

    Status: REVIEWED

    Source sequence(s)
    AL603764
    Consensus CDS
    CCDS44490.1
    UniProtKB/Swiss-Prot
    Q9UGM3, Q9Y4V9
    Related
    ENSP00000357905.3, ENST00000368909.7
    Conserved Domains (6) summary
    smart00042
    Location:17751874
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21272379
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20082116
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22332379
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  5. NM_017579.3NP_060049.2  deleted in malignant brain tumors 1 protein isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AL603764
    Consensus CDS
    CCDS44492.1
    UniProtKB/Swiss-Prot
    Q9UGM3
    Related
    ENSP00000357951.3, ENST00000368955.7
    Conserved Domains (6) summary
    smart00042
    Location:17651864
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9831083
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21172369
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:19982106
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22232369
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:728823
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    122560754..122643736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    123456615..123518779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)