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DMBT1 deleted in malignant brain tumors 1 [ Homo sapiens (human) ]

Gene ID: 1755, updated on 8-Jul-2018
Official Symbol
DMBT1provided by HGNC
Official Full Name
deleted in malignant brain tumors 1provided by HGNC
Primary source
HGNC:HGNC:2926
See related
Ensembl:ENSG00000187908 MIM:601969; Vega:OTTHUMG00000019185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAG; GP340; SALSA; muclin
Summary
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]
Expression
Biased expression in duodenum (RPKM 482.0), small intestine (RPKM 157.2) and 1 other tissue See more
Orthologs
See DMBT1 in Genome Data Viewer
Location:
10q26.13
Exon count:
57
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (122560665..122643736)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124320181..124403252)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378525 Neighboring gene age-related maculopathy susceptibility 2 Neighboring gene uncharacterized LOC105378526 Neighboring gene HtrA serine peptidase 1 Neighboring gene chromosome 10 open reading frame 120 Neighboring gene deleted in malignant brain tumors 1 pseudogene 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Aalanine substitution scan reveals amino acids D34, D35, N96, and E101 in gp340 are the critical residues interaction with HIV-1 gp120 PubMed
env HIV-1 gp120 binds peptides (residues 21-40, 66-85, and 91-109) derived from the first scavenger receptor cysteine rich domain (SRCR1) of gp340 with relative high affinity binding activity PubMed
env A 35KDa purified recombinant N-terminal protein of gp340 (SAG) interacts with the V3 domain of HIV-1 gp120 PubMed
env The interaction of gp340 (SAG) with HIV-1 gp120 is enhanced by prebinding of sCD4 to gp120, suggesting that gp340 inhibitory activity is mediated by blocking access of gp120 to its chemokine coreceptor PubMed
env Salivary agglutinin (SAG), a high molecular weight glycoprotein (340 kDa), binds to HIV-1 gp120; SAG binding to gp120 is Ca(2+) dependent and specifically inhibits HIV-1 infectivity PubMed

Go to the HIV-1, Human Interaction Database

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Surfactant metabolism, organism-specific biosystem (from REACTOME)
    Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ61058, MGC164738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent protein binding TAS
Traceable Author Statement
more info
PubMed 
extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
signaling pattern recognition receptor activity TAS
Traceable Author Statement
more info
PubMed 
zymogen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
detection of bacterial lipoprotein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
epithelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
induction of bacterial agglutination TAS
Traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
pattern recognition receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
deleted in malignant brain tumors 1 protein
Names
glycoprotein 340
gp-340
hensin
salivary agglutinin
salivary scavenger and agglutinin
surfactant pulmonary-associated D-binding protein
vomeroglandin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012644.1 RefSeqGene

    Range
    5001..88072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320644.1NP_001307573.1  deleted in malignant brain tumors 1 protein isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 2. The encoded isoform (d) is shorter than isoform b.
    Source sequence(s)
    AJ243212, AJ297935, AL603764, BX640988
    UniProtKB/Swiss-Prot
    Q9UGM3
    Conserved Domains (6) summary
    smart00042
    Location:17751874
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21262378
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20072115
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22322378
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  2. NM_004406.2NP_004397.2  deleted in malignant brain tumors 1 protein isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks multiple in-frame exons in the coding region compared to variant 2. The encoded isoform (a) is shorter than isoform b.
    Source sequence(s)
    AJ297935, AL603764
    Consensus CDS
    CCDS44491.1
    UniProtKB/Swiss-Prot
    Q9UGM3
    Related
    ENSP00000357952.2, ENST00000368956.6
    Conserved Domains (5) summary
    smart00202
    Location:494594
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:14991751
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:11381248
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:16051751
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:499594
    SRCR; Scavenger receptor cysteine-rich domain
  3. NM_007329.2NP_015568.2  deleted in malignant brain tumors 1 protein isoform b precursor

    See identical proteins and their annotated locations for NP_015568.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (b).
    Source sequence(s)
    AJ297935, AL603764
    Consensus CDS
    CCDS44490.1
    UniProtKB/Swiss-Prot
    Q9UGM3
    Related
    ENSP00000357905.3, ENST00000368909.7
    Conserved Domains (6) summary
    smart00042
    Location:17751874
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21272379
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20082116
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22332379
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  4. NM_017579.2NP_060049.2  deleted in malignant brain tumors 1 protein isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform b.
    Source sequence(s)
    AJ297935, AL603764
    Consensus CDS
    CCDS44492.1
    UniProtKB/Swiss-Prot
    Q9UGM3
    Related
    ENSP00000357951.3, ENST00000368955.7
    Conserved Domains (6) summary
    smart00042
    Location:17651864
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9831083
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21172369
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:19982106
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22232369
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:728823
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    122560665..122643736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717660.3XP_006717723.1  deleted in malignant brain tumors 1 protein isoform X9

    Conserved Domains (6) summary
    smart00042
    Location:18881987
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9771077
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22402492
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21212229
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23462492
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:722817
    SRCR; Scavenger receptor cysteine-rich domain
  2. XM_011539399.2XP_011537701.1  deleted in malignant brain tumors 1 protein isoform X12

    Conserved Domains (6) summary
    smart00042
    Location:18721971
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9611061
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22242476
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21052213
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23302476
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:706801
    SRCR; Scavenger receptor cysteine-rich domain
  3. XM_011539396.2XP_011537698.1  deleted in malignant brain tumors 1 protein isoform X10

    Conserved Domains (6) summary
    smart00042
    Location:18881987
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9771077
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22402492
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21212229
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23462492
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:722817
    SRCR; Scavenger receptor cysteine-rich domain
  4. XM_006717665.3XP_006717728.1  deleted in malignant brain tumors 1 protein isoform X13

    Conserved Domains (6) summary
    smart00042
    Location:18721971
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9611061
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22242476
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21052213
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23302476
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:706801
    SRCR; Scavenger receptor cysteine-rich domain
  5. XM_011539388.3XP_011537690.1  deleted in malignant brain tumors 1 protein isoform X1

    UniProtKB/Swiss-Prot
    Q9UGM3
    Related
    ENSP00000342210.4, ENST00000338354.8
    Conserved Domains (6) summary
    smart00042
    Location:19042003
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22562508
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21372245
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23622508
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  6. XM_011539389.3XP_011537691.1  deleted in malignant brain tumors 1 protein isoform X2

    Conserved Domains (6) summary
    smart00042
    Location:19042003
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22552507
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21362244
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23612507
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  7. XM_011539410.3XP_011537712.1  deleted in malignant brain tumors 1 protein isoform X22

    Conserved Domains (6) summary
    smart00042
    Location:17731872
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21252377
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20062114
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22312377
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  8. XM_011539403.3XP_011537705.1  deleted in malignant brain tumors 1 protein isoform X17

    Conserved Domains (6) summary
    smart00042
    Location:17751874
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21272379
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20082116
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22332379
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  9. XM_011539395.3XP_011537697.1  deleted in malignant brain tumors 1 protein isoform X8

    Conserved Domains (6) summary
    smart00042
    Location:18941993
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22462498
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21272235
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23522498
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  10. XM_011539405.3XP_011537707.1  deleted in malignant brain tumors 1 protein isoform X18

    See identical proteins and their annotated locations for XP_011537707.1

    UniProtKB/Swiss-Prot
    Q9UGM3
    Conserved Domains (6) summary
    smart00042
    Location:17751874
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21272379
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20082116
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22332379
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  11. XM_011539394.3XP_011537696.1  deleted in malignant brain tumors 1 protein isoform X7

    Related
    ENSP00000484603.1, ENST00000619379.1
    Conserved Domains (6) summary
    smart00042
    Location:18941993
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22462498
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21272235
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23522498
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  12. XM_011539393.3XP_011537695.1  deleted in malignant brain tumors 1 protein isoform X6

    Related
    OTTHUMP00000020654
    Conserved Domains (6) summary
    smart00042
    Location:18941993
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22462498
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21272235
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23522498
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  13. XM_011539392.3XP_011537694.1  deleted in malignant brain tumors 1 protein isoform X3

    Conserved Domains (6) summary
    smart00042
    Location:18941993
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22462498
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21272235
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23522498
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  14. XM_011539415.3XP_011537717.1  deleted in malignant brain tumors 1 protein isoform X28

    Conserved Domains (5) summary
    smart00202
    Location:9931093
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:14801732
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:11191229
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:15861732
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  15. XM_011539390.3XP_011537692.1  deleted in malignant brain tumors 1 protein isoform X4

    Conserved Domains (6) summary
    smart00042
    Location:18941993
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9831083
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22462498
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21272235
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23522498
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  16. XM_011539409.3XP_011537711.1  deleted in malignant brain tumors 1 protein isoform X20

    Conserved Domains (6) summary
    smart00042
    Location:17731872
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:733833
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21252377
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20062114
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22312377
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  17. XM_024447854.1XP_024303622.1  deleted in malignant brain tumors 1 protein isoform X24

    Conserved Domains (4) summary
    smart00042
    Location:17631862
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:733833
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21152367
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:19962104
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  18. XM_011539407.3XP_011537709.1  deleted in malignant brain tumors 1 protein isoform X19

    Conserved Domains (6) summary
    smart00042
    Location:17731872
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:862962
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21252377
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20062114
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22312377
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  19. XM_011539401.3XP_011537703.1  deleted in malignant brain tumors 1 protein isoform X15

    Conserved Domains (6) summary
    smart00042
    Location:17751874
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:864964
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21272379
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20082116
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22332379
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  20. XM_011539411.3XP_011537713.1  deleted in malignant brain tumors 1 protein isoform X23

    Conserved Domains (6) summary
    smart00042
    Location:17651864
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:854954
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21172369
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:19982106
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22232369
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  21. XM_011539413.3XP_011537715.1  deleted in malignant brain tumors 1 protein isoform X25

    Conserved Domains (6) summary
    smart00042
    Location:16441743
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:733833
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:19962248
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:18771985
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:21022248
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:738833
    SRCR; Scavenger receptor cysteine-rich domain
  22. XM_011539400.3XP_011537702.1  deleted in malignant brain tumors 1 protein isoform X14

    Conserved Domains (6) summary
    smart00042
    Location:17961895
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:885985
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21482400
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20292137
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22542400
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:630725
    SRCR; Scavenger receptor cysteine-rich domain
  23. XM_011539391.3XP_011537693.1  deleted in malignant brain tumors 1 protein isoform X5

    UniProtKB/Swiss-Prot
    Q9UGM3
    Related
    ENSP00000343175.3, OTTHUMP00000020661, ENST00000344338.7
    Conserved Domains (6) summary
    smart00042
    Location:18941993
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9831083
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22462498
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21272235
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23522498
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:728823
    SRCR; Scavenger receptor cysteine-rich domain
  24. XM_011539408.3XP_011537710.1  deleted in malignant brain tumors 1 protein isoform X21

    Conserved Domains (6) summary
    smart00042
    Location:17731872
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:862962
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21252377
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20062114
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22312377
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:607702
    SRCR; Scavenger receptor cysteine-rich domain
  25. XM_011539414.3XP_011537716.1  deleted in malignant brain tumors 1 protein isoform X27

    Conserved Domains (5) summary
    smart00202
    Location:492592
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:14971749
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:11361246
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:16031749
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:12651356
    SRCR; Scavenger receptor cysteine-rich domain
  26. XM_011539398.3XP_011537700.1  deleted in malignant brain tumors 1 protein isoform X11

    Conserved Domains (6) summary
    smart00042
    Location:18831982
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:9721072
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:22352487
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:21162224
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:23412487
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:717812
    SRCR; Scavenger receptor cysteine-rich domain
  27. XM_011539402.3XP_011537704.1  deleted in malignant brain tumors 1 protein isoform X16

    Conserved Domains (6) summary
    smart00042
    Location:17751874
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00202
    Location:864964
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:21272379
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:20082116
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:22332379
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:609704
    SRCR; Scavenger receptor cysteine-rich domain
  28. XM_017015798.1XP_016871287.1  deleted in malignant brain tumors 1 protein isoform X26

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