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evl-18 Cell division control protein 45 homolog [ Caenorhabditis elegans ]

Gene ID: 175481, updated on 8-Mar-2025

Summary

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Official Symbol
evl-18
Official Full Name
Cell division control protein 45 homolog
Primary source
WormBase:WBGene00009372
Locus tag
CELE_F34D10.2
See related
AllianceGenome:WB:WBGene00009372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Located in nucleus. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Mar 2025]
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Genomic context

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See evl-18 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (3729640..3735039, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Chondroitin proteoglycan 4 domain-containing protein Neighboring gene CPSF_A domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans. Gaggioli V, et al. J Cell Biol, 2014 Feb 17. PMID 24535824, Free PMC Article
  2. Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements. Deng L, et al. Mol Cell, 2019 Mar 7. PMID 30849395, Free PMC Article
  3. Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development. Wang X, et al. Biochem Biophys Res Commun, 2007 Aug 10. PMID 17568563
  4. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Franz A, et al. Nat Commun, 2016 Feb 4. PMID 26842564, Free PMC Article
  5. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Franz A, et al. Mol Cell, 2011 Oct 7. PMID 21981920, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cell division control protein 45 homolog
NP_497756.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3729640..3735039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065355.6 → NP_497756.2  Cell division control protein 45 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497756.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMR0
    Conserved Domains (1) summary
    pfam02724
    Location:22 → 566
    CDC45; CDC45-like protein
Nucleotide Protein
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