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evl-18 Cell division control protein 45 homolog [ Caenorhabditis elegans ]

Gene ID: 175481, updated on 23-Nov-2023

Summary

Gene symbol
evl-18
Gene description
Cell division control protein 45 homolog
Primary source
WormBase:WBGene00009372
Locus tag
CELE_F34D10.2
See related
AllianceGenome:WB:WBGene00009372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Located in nucleus. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See evl-18 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (3729640..3735039, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Chondroitin proteoglycan 4 domain-containing protein Neighboring gene CPSF_A domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Cell division control protein 45 homolog
NP_497756.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3729640..3735039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065355.6NP_497756.2  Cell division control protein 45 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497756.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMR0
    Conserved Domains (1) summary
    pfam02724
    Location:22566
    CDC45; CDC45-like protein