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daf-2 Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein [ Caenorhabditis elegans ]

Gene ID: 175410, updated on 9-Sep-2018

Summary

Gene symbol
daf-2
Gene description
Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein
Primary source
WormBase:WBGene00000898
Locus tag
CELE_Y55D5A.5
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See daf-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
17
Sequence:
Chromosome: III; NC_003281.10 (2995919..3028702, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene CUTiclin-Like

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
PTB domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to salt IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to salt IMP
Inferred from Mutant Phenotype
more info
PubMed 
dauer exit IMP
Inferred from Mutant Phenotype
more info
PubMed 
dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat acclimation IGI
Inferred from Genetic Interaction
more info
PubMed 
heat acclimation IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
larval feeding behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of dauer entry IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuromuscular synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of synaptic growth at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dauer entry IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of development, heterochronic IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of eating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of lipid storage IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spanning component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein
NP_001299916.1
  • Confirmed by transcript evidence
NP_001299917.1
  • Confirmed by transcript evidence
NP_001299918.1
  • Confirmed by transcript evidence
NP_001299919.1
  • Confirmed by transcript evidence
NP_001299920.1
  • Confirmed by transcript evidence
NP_497650.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2995919..3028702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065249.4NP_497650.4  Insulin-like receptor subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497650.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q968Y9
    Conserved Domains (5) summary
    cd05032
    Location:12391522
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:12461520
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:10871173
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:360490
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:512627
    Recep_L_domain; Receptor L domain
  2. NM_001312987.1NP_001299916.1  Receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUY1
    Conserved Domains (5) summary
    cd05032
    Location:13211604
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:13281602
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:11691255
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:360490
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:512627
    Recep_L_domain; Receptor L domain
  3. NM_001312988.1NP_001299917.1  Receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXA0
    Conserved Domains (5) summary
    cd05032
    Location:11921475
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:11991473
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:10401126
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:313443
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:465580
    Recep_L_domain; Receptor L domain
  4. NM_001312989.1NP_001299918.1  Receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARZ1
    Conserved Domains (5) summary
    cd05032
    Location:11631446
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:11701444
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:10111097
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:284414
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:436551
    Recep_L_domain; Receptor L domain
  5. NM_001312990.1NP_001299919.1  Uncharacterized protein CELE_Y55D5A.5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUA1
    Conserved Domains (3) summary
    cd05032
    Location:429712
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:436710
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:277363
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. NM_001312991.1NP_001299920.1  Uncharacterized protein CELE_Y55D5A.5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARE8
    Conserved Domains (2) summary
    cd05032
    Location:65348
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:72346
    STYKc; Protein kinase; unclassified specificity

RNA

  1. NR_132448.1 RNA Sequence

    Status: REVIEWED

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