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daf-2 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase [ Caenorhabditis elegans ]

Gene ID: 175410, updated on 28-Oct-2024

Summary

Official Symbol
daf-2
Official Full Name
Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase
Primary source
WormBase:WBGene00000898
Locus tag
CELE_Y55D5A.5
See related
AllianceGenome:WB:WBGene00000898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables PTB domain binding activity; SH2 domain binding activity; and protein kinase binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and regulation of gene expression. Acts upstream of with a negative effect on protein import into nucleus. Located in several cellular components, including axon; neuronal cell body; and non-motile cilium. Is expressed in several structures, including germ line; gonad; nervous system; oocyte; and vulva. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); glucose metabolism disease (multiple); kidney cancer (multiple); liver disease (multiple); and reproductive organ cancer (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor); INSR (insulin receptor); and INSRR (insulin receptor related receptor). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

See daf-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
18
Sequence:
Chromosome: III; NC_003281.10 (2994514..3040846, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene N-acylethanolamine-hydrolyzing acid amidase subunit beta Neighboring gene ncRNA Neighboring gene Mediator complex subunit 8 Neighboring gene MATH domain-containing protein Neighboring gene ncRNA Neighboring gene ZP domain-containing protein Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables PTB domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to salt IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to salt IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dauer exit IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heat acclimation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heat acclimation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in larval feeding behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of dauer entry IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuromuscular synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_negative_effect protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dauer entry IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of development, heterochronic IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of eating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of lipid storage IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reproductive process IEA
Inferred from Electronic Annotation
more info
 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase
NP_001299916.1
  • Confirmed by transcript evidence
NP_001299917.1
  • Confirmed by transcript evidence
NP_001299918.1
  • Confirmed by transcript evidence
NP_001299919.1
  • Confirmed by transcript evidence
NP_001299920.1
  • Confirmed by transcript evidence
NP_497650.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2994514..3040846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065249.7NP_497650.4  Insulin-like receptor subunit beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497650.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AUY1, B5QS63, O16131, Q968Y9
    Conserved Domains (5) summary
    cd05032
    Location:12391522
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:12461520
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:10871173
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:360490
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:512627
    Recep_L_domain; Receptor L domain
  2. NM_001312987.4NP_001299916.1  Insulin-like receptor subunit beta [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUY1
    Conserved Domains (5) summary
    cd05032
    Location:13211604
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:13281602
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:11691255
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:360490
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:512627
    Recep_L_domain; Receptor L domain
  3. NM_001312988.3NP_001299917.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXA0
    Conserved Domains (5) summary
    cd05032
    Location:11921475
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:11991473
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:10401126
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:313443
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:465580
    Recep_L_domain; Receptor L domain
  4. NM_001312989.3NP_001299918.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARZ1
    Conserved Domains (5) summary
    cd05032
    Location:11631446
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:11701444
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:10111097
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:284414
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:436551
    Recep_L_domain; Receptor L domain
  5. NM_001312990.3NP_001299919.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUA1
    Conserved Domains (3) summary
    cd05032
    Location:429712
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    smart00221
    Location:436710
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:277363
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. NM_001312991.3NP_001299920.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARE8
    Conserved Domains (1) summary
    cd05032
    Location:65348
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

RNA

  1. NR_132448.1 RNA Sequence

    Status: REVIEWED