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uaf-1 Splicing factor U2AF 65 kDa subunit [ Caenorhabditis elegans ]

Gene ID: 175270, updated on 17-Nov-2020

Summary

Gene symbol
uaf-1
Gene description
Splicing factor U2AF 65 kDa subunit
Primary source
WormBase:WBGene00006697
Locus tag
CELE_Y92C3B.2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See uaf-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (1062794..1076555, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene S1 motif domain-containing protein Neighboring gene UBR-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Methyltransf_21 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ras-related protein Rab-18 Neighboring gene ncRNA Neighboring gene KNL (kinetochore null) Binding Protein Neighboring gene RING-type domain-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the uaf-1 gene: The uaf-1 gene is conserved in human, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
poly-pyrimidine tract binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-mRNA 3'-splice site binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA 3'-splice site recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
nematode larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
Splicing factor U2AF 65 kDa subunit
NP_001022967.1
  • Confirmed by transcript evidence
NP_001367384.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1062794..1076555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027796.4NP_001022967.1  Splicing factor U2AF 65 kDa subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022967.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90978
    Conserved Domains (3) summary
    cd12230
    Location:183264
    RRM1_U2AF65; RNA recognition motif 1 found in U2 large nuclear ribonucleoprotein auxiliary factor U2AF 65 kDa subunit (U2AF65) and similar proteins
    cd12231
    Location:291366
    RRM2_U2AF65; RNA recognition motif 2 found in U2 large nuclear ribonucleoprotein auxiliary factor U2AF 65 kDa subunit (U2AF65) and similar proteins
    cd12232
    Location:397484
    RRM3_U2AF65; RNA recognition motif 3 found in U2 large nuclear ribonucleoprotein auxiliary factor U2AF 65 kDa subunit (U2AF65) and similar proteins
  2. NM_001381724.1NP_001367384.1  Splicing factor U2AF 65 kDa subunit [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    TIGR01642
    Location:1143
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
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