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xpd-1 General transcription and DNA repair factor IIH helicase subunit XPD [ Caenorhabditis elegans ]

Gene ID: 175190, updated on 23-Nov-2023

Summary

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Gene symbol
xpd-1
Gene description
General transcription and DNA repair factor IIH helicase subunit XPD
Primary source
WormBase:WBGene00021752
Locus tag
CELE_Y50D7A.2
See related
AllianceGenome:WB:WBGene00021752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA helicase activity and damaged DNA binding activity. Predicted to be involved in several processes, including nucleotide-excision repair; positive regulation of mitotic recombination; and transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (265090..283009)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene N-alpha-acetyltransferase 16, NatA auxiliary subunit Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein;phosphorylase kinase Neighboring gene ncRNA Neighboring gene Transcriptional regulatory protein Neighboring gene 30S ribosomal protein S15;Peptidase metallopeptidase domain-containing protein Neighboring gene DUF295 domain-containing protein;F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans: a model of Fanconi anemia and ICL repair. Youds JL, et al. Mutat Res, 2009 Jul 31. PMID 19059419
  2. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article
  3. DNA repair. O'Neil N, et al. WormBook, 2006 Jan 13. PMID 18050489, Free PMC Article
  4. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
General transcription and DNA repair factor IIH helicase subunit XPD
NP_001348650.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    265090..283009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361883.3 → NP_001348650.1  General transcription and DNA repair factor IIH helicase subunit XPD [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3L2
    Conserved Domains (1) summary
    TIGR00604
    Location:7 → 702
    rad3; DNA repair helicase (rad3)
Nucleotide Protein
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