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rpoa-1 DNA-directed RNA polymerase;DNA-directed RNA polymerase subunit [ Caenorhabditis elegans ]

Gene ID: 175015, updated on 2-Nov-2024

Summary

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Official Symbol
rpoa-1
Official Full Name
DNA-directed RNA polymerase;DNA-directed RNA polymerase subunit
Primary source
WormBase:WBGene00012999
Locus tag
CELE_Y48E1A.1
See related
AllianceGenome:WB:WBGene00012999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpoa-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (13670626..13694795, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene WH1 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Potassium voltage-gated channel subfamily KQT member 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
  2. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase;DNA-directed RNA polymerase subunit
NP_001022450.1
  • Confirmed by transcript evidence
NP_001022451.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13670626..13694795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027279.5 → NP_001022450.1  DNA-directed RNA polymerase subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022450.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED21
    Conserved Domains (3) summary
    cd02735
    Location:1223 → 1711
    RNAP_I_Rpa1_C; Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
    PRK14977
    Location:10 → 1713
    PRK14977; bifunctional DNA-directed RNA polymerase A'/A'' subunit; Provisional
    cd01435
    Location:23 → 1040
    RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain

  2. NM_001027280.6 → NP_001022451.1  DNA-directed RNA polymerase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022451.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDG7
    Conserved Domains (1) summary
    cl29012
    Location:2 → 94
    RNAP_largest_subunit_C; Largest subunit of RNA polymerase (RNAP), C-terminal domain
Nucleotide Protein
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