daf-22 Non-specific lipid-transfer protein-like 2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: daf-22
Gene description: Non-specific lipid-transfer protein-like 2
Primary source: WormBase:WBGene00013284
Locus tag: CELE_Y57A10C.6
See related: AllianceGenome:WB:WBGene00013284
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables propanoyl-CoA C-acyltransferase activity. Involved in several processes, including ascaroside biosynthetic process; dauer larval development; and olfactory learning. Located in peroxisome. Is expressed in body wall musculature; hypodermis; intestine; and neurons. Used to study obesity. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See daf-22 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (12423518..12425694, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y57A10C.6 (e-PCR)
- UniSTS:310316

Homology

Homologs of the daf-22 gene: The daf-22 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, M.oryzae, N.crassa, and frog.
Orthologs

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables propanoyl-CoA C-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables propanoyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ascaroside biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer exit	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pheromone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Non-specific lipid-transfer protein-like 2

NP_496639.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12423518..12425694 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064238.7 → NP_496639.1 Non-specific lipid-transfer protein-like 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496639.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDP2

Conserved Domains (2) summary

PRK08256
Location:7 → 388

PRK08256; lipid-transfer protein; Provisional

cd00829
Location:11 → 388

SCP-x_thiolase; Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal ...