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mcm-2 DNA replication licensing factor MCM2 [ Caenorhabditis elegans ]

Gene ID: 174841, updated on 23-Nov-2023

Summary

Gene symbol
mcm-2
Gene description
DNA replication licensing factor MCM2
Primary source
WormBase:WBGene00003154
Locus tag
CELE_Y17G7B.5
See related
AllianceGenome:WB:WBGene00003154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication initiation. Located in condensed chromosome and pronucleus. Is expressed in excretory cell; intestine; nervous system; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See mcm-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (12001509..12006625, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2 Neighboring gene Metallo-beta-lactamase domain-containing protein Neighboring gene Deoxyhypusine synthase Neighboring gene Activin_recp domain-containing protein;DUF281 domain-containing protein Neighboring gene Globin family profile domain-containing protein Neighboring gene ncRNA Neighboring gene RNA exonuclease 4 Neighboring gene F-box domain-containing protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
 
part_of MCM complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM2
NP_001022416.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12001509..12006625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027245.8NP_001022416.1  DNA replication licensing factor MCM2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022416.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXI9
    Conserved Domains (4) summary
    cd00009
    Location:461639
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00350
    Location:270777
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:48103
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:171286
    MCM_N; MCM N-terminal domain