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mcm-2 DNA helicase [ Caenorhabditis elegans ]

Gene ID: 174841, updated on 4-Oct-2020

Summary

Gene symbol
mcm-2
Gene description
DNA helicase
Primary source
WormBase:WBGene00003154
Locus tag
CELE_Y17G7B.5
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See mcm-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (12001509..12006625, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2 Neighboring gene Lactamase_B domain-containing protein Neighboring gene Deoxyhypusine synthase Neighboring gene hypothetical protein Neighboring gene GLoBin related Neighboring gene ncRNA Neighboring gene Exonuclease domain-containing protein Neighboring gene F-box domain-containing protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the mcm-2 gene: The mcm-2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MCM complex IEA
Inferred from Electronic Annotation
more info
 
MCM complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
pronucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA helicase
NP_001022416.1
  • Confirmed by transcript evidence
NP_001022417.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12001509..12006625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027245.8NP_001022416.1  DNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022416.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXI9
    Conserved Domains (4) summary
    cd00009
    Location:461639
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00350
    Location:270777
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:48103
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:171286
    MCM_N; MCM N-terminal domain
  2. NM_001027246.5NP_001022417.1  DNA helicase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022417.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K7J6
    Conserved Domains (1) summary
    pfam12619
    Location:4888
    MCM2_N; Mini-chromosome maintenance protein 2
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