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xpf-1 ERCC4 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174793, updated on 9-Dec-2024

Summary

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Official Symbol
xpf-1
Official Full Name
ERCC4 domain-containing protein
Primary source
WormBase:WBGene00008140
Locus tag
CELE_C47D12.8
See related
AllianceGenome:WB:WBGene00008140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables enzyme binding activity. Involved in several processes, including meiotic nuclear division; negative regulation of nematode larval development; and positive regulation of embryonic development. Predicted to be part of nucleotide-excision repair factor 1 complex. Is expressed in several structures, including body wall musculature; germ cell; hypodermis; intestine; and pharyngeal gland cell. Used to study Cockayne syndrome; Fanconi anemia; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; polyneuropathy due to drug; and xeroderma pigmentosum (multiple). Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See xpf-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (11696171..11705371)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene CUB domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase Neighboring gene inositol-3-phosphate synthase Neighboring gene ncRNA Neighboring gene Malate dehydrogenase Neighboring gene Cyclopropane-fatty-acyl-phospholipid synthase Neighboring gene MARVEL domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency. Meier B, et al. Genome Res, 2014 Oct. PMID 25030888, Free PMC Article
  2. Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans. Marchal L, et al. Mech Ageing Dev, 2021 Dec. PMID 34562508, Free PMC Article
  3. Meiotic DNA break repair can utilize homolog-independent chromatid templates in C. elegans. Toraason E, et al. Curr Biol, 2021 Apr 12. PMID 33740427, Free PMC Article
  4. Crossover recombination mediated by HIM-18/SLX4-associated nucleases. Saito TT, et al. Worm, 2014. PMID 25057454, Free PMC Article
  5. Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis. O'Neil NJ, et al. PLoS Genet, 2013. PMID 23874209, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1.
    Title: Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in resolution of meiotic recombination intermediates IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of nucleotide-excision repair factor 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ERCC4 domain-containing protein
NP_496498.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11696171..11705371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064097.5 → NP_496498.1  ERCC4 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496498.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBZ1
    Conserved Domains (1) summary
    TIGR00596
    Location:106 → 855
    rad1; DNA repair protein (rad1)
Nucleotide Protein
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