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age-1 Phosphatidylinositol 3-kinase age-1 [ Caenorhabditis elegans ]

Gene ID: 174762, updated on 19-Aug-2018

Summary

Gene symbol
age-1
Gene description
Phosphatidylinositol 3-kinase age-1
Primary source
WormBase:WBGene00000090
Locus tag
CELE_B0334.8
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See age-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (11519708..11527054, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene Mediator of RNA polymerase II transcription subunit 8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
1-phosphatidylinositol-3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
1-phosphatidylinositol-3-kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to salt IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to salt IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemosensory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
dauer entry IMP
Inferred from Mutant Phenotype
more info
PubMed 
dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway involved in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic growth at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to salt IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Phosphatidylinositol 3-kinase age-1
NP_001300488.1
  • Confirmed by transcript evidence
NP_496462.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11519708..11527054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064061.4NP_496462.2  Phosphatidylinositol 3-kinase age-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496462.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94125
    Conserved Domains (5) summary
    cd08380
    Location:420574
    C2_PI3K_like; C2 domain present in phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:98177
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:241360
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    smart00145
    Location:606798
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
    cl21453
    Location:7931181
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001313559.1NP_001300488.1  Phosphatidylinositol 3-kinase age-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARF0
    Conserved Domains (1) summary
    cl21453
    Location:775
    PKc_like; Protein Kinases, catalytic domain
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