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Mpeg1 macrophage expressed gene 1 [ Mus musculus (house mouse) ]

Gene ID: 17476, updated on 8-Dec-2022

Summary

Official Symbol
Mpeg1provided by MGI
Official Full Name
macrophage expressed gene 1provided by MGI
Primary source
MGI:MGI:1333743
See related
Ensembl:ENSMUSG00000046805 AllianceGenome:MGI:1333743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P-2; MPS1; Mpg-1
Summary
Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and pore formation in membrane of other organism. Located in phagocytic vesicle. Is expressed in several structures, including blood vessel; central nervous system; developing vasculature of reproductive system; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MPEG1 (macrophage expressed 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 17.8), lung adult (RPKM 13.2) and 22 other tissues See more
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Genomic context

See Mpeg1 in Genome Data Viewer
Location:
19; 19 A
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (12438134..12442649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (12460770..12465285)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily A member 3 Neighboring gene pore forming protein-like Neighboring gene deltex 4, E3 ubiquitin ligase Neighboring gene uncharacterized LOC118568405 Neighboring gene family with sequence similarity 111, member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150002, MGC150003

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
macrophage-expressed gene 1 protein
Names
macrophage gene 1 protein
perforin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374668.1NP_001361597.1  macrophage-expressed gene 1 protein precursor

    Status: VALIDATED

    Source sequence(s)
    AC151730
    Conserved Domains (1) summary
    pfam01823
    Location:125341
    MACPF; MAC/Perforin domain
  2. NM_010821.2NP_034951.2  macrophage-expressed gene 1 protein precursor

    Status: VALIDATED

    Source sequence(s)
    AC151730
    Related
    ENSMUSP00000108573.4, ENSMUST00000081035.9
    Conserved Domains (1) summary
    pfam01823
    Location:125341
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    12438134..12442649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)