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Gbp4 guanylate binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 17472, updated on 8-Dec-2022

Summary

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Official Symbol
Gbp4provided by MGI
Official Full Name
guanylate binding protein 4provided by MGI
Primary source
MGI:MGI:97072
See related
Ensembl:ENSMUSG00000079363 AllianceGenome:MGI:97072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpa2; Mag-2; Mpa-2
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within several processes, including cellular response to interferon-gamma; negative regulation of macromolecule metabolic process; and negative regulation of protein import into nucleus. Predicted to be active in cytoplasmic vesicle. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 15.2), bladder adult (RPKM 6.1) and 10 other tissues See more
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Genomic context

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See Gbp4 in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105263633..105287452, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105115767..105139586, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene guanylate-binding protein 8 Neighboring gene guanylate-binding protein 9 Neighboring gene predicted gene, 53274 Neighboring gene predicted gene 9640

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In silico and in vitro characterization of mGBP4 splice variants. Konermann C, et al. DNA Cell Biol, 2007 Dec. PMID 17919070
  2. Identification and characterization of a new gene family induced during macrophage activation. Wynn TA, et al. J Immunol, 1991 Dec 15. PMID 1753106
  3. Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro. Nguyen TT, et al. J Interferon Cytokine Res, 2002 Aug. PMID 12396730
  4. Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. Hu Y, et al. J Immunol, 2011 Dec 15. PMID 22095711
  5. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Olszewski MA, et al. J Interferon Cytokine Res, 2006 May. PMID 16689661

See all (12) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4245

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein ubiquitination IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
macrophage activation 2
Names
guanylate nucleotide binding protein 4
guanylate-binding protein 4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256005.1 → NP_001242934.1  macrophage activation 2 isoform 1

    See identical proteins and their annotated locations for NP_001242934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3.
    Source sequence(s)
    EF494423
    Consensus CDS
    CCDS57368.1
    UniProtKB/TrEMBL
    A4UUI3
    Related
    ENSMUSP00000098522.4, ENSMUST00000100962.8
    Conserved Domains (2) summary
    pfam02841
    Location:289 → 582
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16 → 287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001359079.1 → NP_001346008.1  macrophage activation 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC123697, AC144914
    Conserved Domains (2) summary
    pfam02841
    Location:302 → 595
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:29 → 300
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001359080.1 → NP_001346009.1  macrophage activation 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AC123697, AC144914
    UniProtKB/TrEMBL
    B9EJ74
    Conserved Domains (2) summary
    pfam02841
    Location:153 → 446
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001359081.1 → NP_001346010.1  macrophage activation 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AC123697, AC144914
    UniProtKB/TrEMBL
    B9EJ74
    Conserved Domains (2) summary
    pfam02841
    Location:153 → 446
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001359082.1 → NP_001346011.1  macrophage activation 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AC123697, AC144914
    UniProtKB/TrEMBL
    B9EJ74
    Conserved Domains (2) summary
    pfam02841
    Location:153 → 446
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. NM_008620.4 → NP_032646.2  macrophage activation 2 isoform 2

    See identical proteins and their annotated locations for NP_032646.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    EF494424
    UniProtKB/TrEMBL
    B9EJ74, Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:153 → 446
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105263633..105287452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534805.4 → XP_006534868.1  macrophage activation 2 isoform X1

    See identical proteins and their annotated locations for XP_006534868.1

    UniProtKB/TrEMBL
    A4UUI3
    Conserved Domains (2) summary
    pfam02841
    Location:289 → 582
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16 → 287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006534804.4 → XP_006534867.1  macrophage activation 2 isoform X1

    See identical proteins and their annotated locations for XP_006534867.1

    UniProtKB/TrEMBL
    A4UUI3
    Conserved Domains (2) summary
    pfam02841
    Location:289 → 582
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16 → 287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_011249411.4 → XP_011247713.1  macrophage activation 2 isoform X1

    See identical proteins and their annotated locations for XP_011247713.1

    UniProtKB/TrEMBL
    A4UUI3
    Conserved Domains (2) summary
    pfam02841
    Location:289 → 582
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16 → 287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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