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crn-5 Cell-death-Related Nuclease [ Caenorhabditis elegans ]

Gene ID: 174634, updated on 19-Aug-2018

Summary

Gene symbol
crn-5
Gene description
Cell-death-Related Nuclease
Primary source
WormBase:WBGene00000798
Locus tag
CELE_C14A4.5
Gene type
protein coding
RNA name
Cell-death-Related Nuclease
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See crn-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (10592762..10593499)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative glycosyltransferase C14A4.3 Neighboring gene Cell-death-Related Nuclease Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Pathways from BioSystems

General gene information

Markers

Homology

  • Homologs of the crn-5 gene: The crn-5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, E.gossypii, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
3'-5' exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic DNA fragmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyadenylation-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of deoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exosome (RNase complex) IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Cell-death-Related Nuclease
NP_496284.1
  • Product from WormBase gene class crn;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10592762..10593499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063883.3NP_496284.1  Cell-death-Related Nuclease [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG59
    Conserved Domains (1) summary
    cd11372
    Location:5202
    RNase_PH_RRP46; RRP46 subunit of eukaryotic exosome
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