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plc-3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 [ Caenorhabditis elegans ]

Gene ID: 174586, updated on 9-Jun-2025
Official Symbol
plc-3
Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
Primary source
WormBase:WBGene00004038
Locus tag
CELE_T01E8.3
See related
AllianceGenome:WB:WBGene00004038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in sleep. Predicted to be active in ruffle membrane. Is expressed in ALA; gonad; intestine; and non-striated muscle. Human ortholog(s) of this gene implicated in autoinflammation, antibody deficiency, and immune dysregulation syndrome; familial cold autoinflammatory syndrome 3; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to several human genes including PLCG2 (phospholipase C gamma 2). [provided by Alliance of Genome Resources, Jun 2025]
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Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (10222877..10229440)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Regulator of fusion ref-1 Neighboring gene Serpentine Receptor, class H Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene UBX domain-containing protein 5 Neighboring gene F-box/WD repeat-containing protein mec-15

Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans. Walker DS, et al. PLoS Genet, 2009 Sep. PMID 19730689, Free PMC Article
  2. High-throughput transcriptome sequencing reveals extremely high doses of ionizing radiation-response genes in Caenorhabditis elegans. Xu Y, et al. Toxicol Res (Camb), 2019 Sep 1. PMID 31588352, Free PMC Article
  3. Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling. Xing J, et al. Am J Physiol Cell Physiol, 2010 Feb. PMID 19923421, Free PMC Article
  4. Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans. Vázquez-Manrique RP, et al. PLoS Genet, 2008 Mar 28. PMID 18369461, Free PMC Article
  5. DEC-7/SUSD2, a sushi domain-containing protein, regulates an ultradian behavior mediated by intestinal epithelial Ca(2+) oscillations in Caenorhabditis elegans. Laboy JT, et al. Am J Physiol Cell Physiol, 2023 May 1. PMID 37067458, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of epithelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
NP_496205.2
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10222877..10229440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063804.5 → NP_496205.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496205.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22070
    Conserved Domains (8) summary
    smart00149
    Location:983 → 1092
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1110 → 1222
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:351 → 494
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:710 → 813
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:600 → 696
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    smart00326
    Location:833 → 886
    SH3; Src homology 3 domains
    pfam09279
    Location:278 → 350
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl17171
    Location:74 → 191
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22070.2

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