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plc-3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 [ Caenorhabditis elegans ]

Gene ID: 174586, updated on 5-Sep-2019

Summary

Gene symbol
plc-3
Gene description
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
Primary source
WormBase:WBGene00004038
Locus tag
CELE_T01E8.3
Gene type
protein coding
RNA name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See plc-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (10222877..10229440)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene REgulator of Fusion Neighboring gene Serpentine Receptor, class H Neighboring gene hypothetical protein Neighboring gene UBX domain-containing protein 5 Neighboring gene F-box/WD repeat-containing protein mec-15

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inositol trisphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
NP_496205.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10222877..10229440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063804.5NP_496205.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496205.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22070
    Conserved Domains (8) summary
    smart00149
    Location:9831092
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:11101222
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:351494
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:710813
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:600696
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    smart00326
    Location:833886
    SH3; Src homology 3 domains
    pfam09279
    Location:278350
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl17171
    Location:74191
    PH-like; Pleckstrin homology-like domain
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