plc-3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: plc-3
Gene description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
Primary source: WormBase:WBGene00004038
Locus tag: CELE_T01E8.3
Gene type: protein coding
RNA name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

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See plc-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (10222877..10229440)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Genotypes

See SNP Geneview Report

Pathways from BioSystems

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AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
C-type lectin receptors (CLRs), organism-specific biosystemcomputationally inferred pathway (not manually curated)
CLEC7A (Dectin-1) signaling, organism-specific biosystem (from REACTOME)
CLEC7A (Dectin-1) signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Calcium signaling pathway, organism-specific biosystem (from KEGG)
Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Calcium signaling pathway, conserved biosystem (from KEGG)
Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR1, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR2, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR3, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR4, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
GPVI-mediated activation cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
Generation of second messenger molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
ISG15 antiviral mechanism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune responses in the epidermis, organism-specific biosystem (from WikiPathways)
Immune responses in the epidermis, organism-specific biosystem"Regulation of immune responses in the epidermis by two largely parallel pathways. The p38 MAPK pathway (proteins in this pathway are in black letters) regulates the expression nlp-29, an AMP-encodin...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inositol phosphate metabolism, organism-specific biosystem (from KEGG)
Inositol phosphate metabolism, organism-specific biosystem
Inositol phosphate metabolism
Inositol phosphate metabolism, organism-specific biosystem (from REACTOME)
Inositol phosphate metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inositol phosphate metabolism, conserved biosystem (from KEGG)
Inositol phosphate metabolism, conserved biosystem
Inositol phosphate metabolism
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4, organism-specific biosystem (from KEGG)
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4, conserved biosystem (from KEGG)
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Phosphatidylinositol signaling system, organism-specific biosystem (from KEGG)
Phosphatidylinositol signaling system, organism-specific biosystem
Phosphatidylinositol signaling system
Phosphatidylinositol signaling system, conserved biosystem (from KEGG)
Phosphatidylinositol signaling system, conserved biosystem
Phosphatidylinositol signaling system
Phospholipase C-mediated cascade: FGFR1, organism-specific biosystem (from REACTOME)
Phospholipase C-mediated cascade: FGFR1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Phospholipase C-mediated cascade; FGFR2, organism-specific biosystem (from REACTOME)
Phospholipase C-mediated cascade; FGFR2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Phospholipase C-mediated cascade; FGFR3, organism-specific biosystem (from REACTOME)
Phospholipase C-mediated cascade; FGFR3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Phospholipase C-mediated cascade; FGFR4, organism-specific biosystem (from REACTOME)
Phospholipase C-mediated cascade; FGFR4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR1, organism-specific biosystem (from REACTOME)
Signaling by FGFR1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR2, organism-specific biosystem (from REACTOME)
Signaling by FGFR2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR3, organism-specific biosystem (from REACTOME)
Signaling by FGFR3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR4, organism-specific biosystem (from REACTOME)
Signaling by FGFR4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystem (from REACTOME)
Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TCR signaling, organism-specific biosystem (from REACTOME)
TCR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T01E8.3 (e-PCR)
- UniSTS:307889

Homology

Homologs of the plc-3 gene: The plc-3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and A.thaliana.
Orthologs

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
hydrolase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
inositol trisphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
lipid catabolic process	IEA Inferred from Electronic Annotation more info
lipid metabolic process	IEA Inferred from Electronic Annotation more info
phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of epithelial cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info
sleep	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3

NP_496205.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10222877..10229440

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063804.5 → NP_496205.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496205.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22070

Conserved Domains (8) summary

smart00149
Location:983 → 1092

PLCYc; Phospholipase C, catalytic domain (part); domain Y

cd00275
Location:1110 → 1222

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08592
Location:351 → 494

PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma

cd09932
Location:710 → 813

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:600 → 696

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

smart00326
Location:833 → 886

SH3; Src homology 3 domains

pfam09279
Location:278 → 350

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl17171
Location:74 → 191

PH-like; Pleckstrin homology-like domain