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eif-3.F Eukaryotic translation initiation factor 3 subunit F [ Caenorhabditis elegans ]

Gene ID: 174478, updated on 4-Feb-2026
Official Symbol
eif-3.F
Official Full Name
Eukaryotic translation initiation factor 3 subunit F
Primary source
WormBase:WBGene00001229
Locus tag
CELE_D2013.7
See related
AllianceGenome:WB:WBGene00001229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Involved in translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 67. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Jul 2025]
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See eif-3.F in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (9331643..9333970)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Dynamin-like GTPase OPA1, mitochondrial Neighboring gene GRAM domain-containing protein Neighboring gene ncRNA Neighboring gene Sterol regulatory element-binding protein cleavage-activating protein;WD_REPEATS_REGION domain-containing protein Neighboring gene Tubulin--tyrosine ligase-like protein 12

Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Lee EC, et al. Am J Physiol Cell Physiol, 2012 Dec 15. PMID 23076791, Free PMC Article
  2. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Chen D, et al. Aging Cell, 2007 Aug. PMID 17521386, Free PMC Article
  3. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Luke-Glaser S, et al. Mol Cell Biol, 2007 Jun. PMID 17403899, Free PMC Article
  4. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
  5. Lifespan regulation by evolutionarily conserved genes essential for viability. Curran SP, et al. PLoS Genet, 2007 Apr 6. PMID 17411345, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal-dependent deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Eukaryotic translation initiation factor 3 subunit F
NP_495988.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9331643..9333970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063587.7 → NP_495988.1  Eukaryotic translation initiation factor 3 subunit F

    See identical proteins and their annotated locations for NP_495988.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18967
    Conserved Domains (1) summary
    cd08064
    Location:7 → 291
    MPN_eIF3f; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18967.1

Gene LinkOut

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