wdfy-2 WD repeat and FYVE domain-containing protein 2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: wdfy-2
Gene description: WD repeat and FYVE domain-containing protein 2
Primary source: WormBase:WBGene00008402
Locus tag: CELE_D2013.2
See related: AllianceGenome:WB:WBGene00008402
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in endocytosis. Orthologous to several human genes including WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See wdfy-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (9319865..9321878)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2013.3 (e-PCR)
- UniSTS:307400

D2013.2 (e-PCR)
- UniSTS:309477

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat and FYVE domain-containing protein 2

NP_495983.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9319865..9321878

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063582.4 → NP_495983.1 WD repeat and FYVE domain-containing protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495983.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18964

Conserved Domains (4) summary

COG2319
Location:26 → 289

WD40; WD40 repeat [General function prediction only]

cd15718
Location:284 → 353

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:124 → 163

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 281

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...