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csa-1 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174474, updated on 2-Dec-2025
Official Symbol
csa-1
Official Full Name
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00008403
Locus tag
CELE_D2013.3
See related
AllianceGenome:WB:WBGene00008403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and transcription-coupled nucleotide-excision repair. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
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Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (9317551..9319726, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Acyl-CoA synthetase 7 Neighboring gene Golgi apparatus protein 1 Neighboring gene Tyrosine-protein kinase receptor cam-1 Neighboring gene ncRNA Neighboring gene WD repeat and FYVE domain-containing protein 2 Neighboring gene ncRNA Neighboring gene Ras-related protein rab-39

Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A C. elegans homolog of the Cockayne syndrome complementation group A gene. Babu V, et al. DNA Repair (Amst), 2014 Dec. PMID 25453470, Free PMC Article
  2. MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO. Bianco JN, et al. Nucleic Acids Res, 2018 Jul 6. PMID 29788264, Free PMC Article
  3. A C. elegans model for neurodegeneration in Cockayne syndrome. Lopes AFC, et al. Nucleic Acids Res, 2020 Nov 4. PMID 33021672, Free PMC Article
  4. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Wilson DM 3rd, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934497, Free PMC Article
  5. The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Bujarrabal-Dueso A, et al. Nat Struct Mol Biol, 2023 Apr. PMID 36959262, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription-coupled nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription-coupled nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul4A-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-excision repair complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_495982.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9317551..9319726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063581.5 → NP_495982.1  WD_REPEATS_REGION domain-containing protein

    See identical proteins and their annotated locations for NP_495982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18963
    Conserved Domains (3) summary
    COG2319
    Location:49 → 267
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:53 → 95
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:44 → 264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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