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Me1 malic enzyme 1, NADP(+)-dependent, cytosolic [ Mus musculus (house mouse) ]

Gene ID: 17436, updated on 8-Feb-2024

Summary

Official Symbol
Me1provided by MGI
Official Full Name
malic enzyme 1, NADP(+)-dependent, cytosolicprovided by MGI
Primary source
MGI:MGI:97043
See related
Ensembl:ENSMUSG00000032418 AllianceGenome:MGI:97043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mod1; Mdh-1; Mod-1; D9Ertd267e
Summary
Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in carboxylic acid metabolic process; regulation of NADP metabolic process; and response to hormone. Located in mitochondrion. Is expressed in several structures, including cardiovascular system; central nervous system; cranium; eye; and genitourinary system. Orthologous to human ME1 (malic enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 140.3), mammary gland adult (RPKM 130.2) and 16 other tissues See more
Orthologs
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Genomic context

See Me1 in Genome Data Viewer
Location:
9 E3.1; 9 46.58 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86463416..86577967, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86581363..86695914, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DOP1 leucine zipper like protein A Neighboring gene STARR-positive B cell enhancer ABC_E9332 Neighboring gene phosphoglucomutase 3 Neighboring gene STARR-positive B cell enhancer ABC_E10572 Neighboring gene RWD domain containing 2A Neighboring gene STARR-seq mESC enhancer starr_24835 Neighboring gene RIKEN cDNA A330041J22 gene Neighboring gene predicted gene, 22138 Neighboring gene serine protease 35

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC91072

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables malate dehydrogenase (decarboxylating) (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables malic enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables malic enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxaloacetate decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NADH metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in malate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in malate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NADP-dependent malic enzyme
Names
NADP-ME
malic enzyme, supernatant
NP_001185862.1
NP_032641.2
XP_011240968.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198933.1NP_001185862.1  NADP-dependent malic enzyme isoform 2

    See identical proteins and their annotated locations for NP_001185862.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon at its 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK077968, AK163403, AV363687
    Consensus CDS
    CCDS81047.1
    UniProtKB/TrEMBL
    Q3TQP6, Q921S3
    Related
    ENSMUSP00000140887.2, ENSMUST00000185374.2
    Conserved Domains (3) summary
    cd05312
    Location:250527
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:7531
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:59240
    malic; Malic enzyme, N-terminal domain
  2. NM_008615.2NP_032641.2  NADP-dependent malic enzyme isoform 1

    See identical proteins and their annotated locations for NP_032641.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK077968, AV363687, CJ070715
    Consensus CDS
    CCDS23383.1
    UniProtKB/Swiss-Prot
    P06801, Q9DBF9
    UniProtKB/TrEMBL
    Q921S3
    Related
    ENSMUSP00000034989.9, ENSMUST00000034989.15
    Conserved Domains (3) summary
    cd05312
    Location:270547
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:2551
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:79260
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    86463416..86577967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242666.2XP_011240968.1  NADP-dependent malic enzyme isoform X1

    UniProtKB/TrEMBL
    Q921S3
    Conserved Domains (1) summary
    PLN03129
    Location:1476
    PLN03129; NADP-dependent malic enzyme; Provisional