Format

Send to:

Choose Destination

pde-4 Phosphodiesterase;Probable 3',5'-cyclic phosphodiesterase pde-4 [ Caenorhabditis elegans ]

Gene ID: 174235, updated on 5-Sep-2019

Summary

Gene symbol
pde-4
Gene description
Phosphodiesterase;Probable 3',5'-cyclic phosphodiesterase pde-4
Primary source
WormBase:WBGene00020114
Locus tag
CELE_R153.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See pde-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
17
Sequence:
Chromosome: II; NC_003280.10 (7627244..7653856, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ALS/FTD Associated gene homolog

Bibliography

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cAMP-mediated signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Phosphodiesterase;Probable 3',5'-cyclic phosphodiesterase pde-4
NP_001040798.1
  • Confirmed by transcript evidence
NP_001293472.1
  • Confirmed by transcript evidence
NP_495600.1
  • Partially confirmed by transcript evidence
NP_495601.1
  • Partially confirmed by transcript evidence
NP_871944.1
  • Confirmed by transcript evidence
NP_871945.1
  • Confirmed by transcript evidence
NP_871946.1
  • Confirmed by transcript evidence
NP_871947.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7627244..7653856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182146.4NP_871946.1  Probable 3',5'-cyclic phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871946.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
    Conserved Domains (1) summary
    pfam00233
    Location:344585
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_001306543.2NP_001293472.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293472.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FCW6
    Conserved Domains (1) summary
    pfam00233
    Location:356597
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. NM_063199.4NP_495600.1  Probable 3',5'-cyclic phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
    Conserved Domains (1) summary
    pfam00233
    Location:358599
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. NM_182144.4NP_871944.1  Probable 3',5'-cyclic phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871944.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
    Conserved Domains (1) summary
    pfam00233
    Location:331572
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  5. NM_063200.2NP_495601.1  Probable 3',5'-cyclic phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495601.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
    Conserved Domains (1) summary
    pfam00233
    Location:281522
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  6. NM_001047333.5NP_001040798.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2V4U0
    Conserved Domains (1) summary
    pfam00233
    Location:405646
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  7. NM_182145.4NP_871945.1  Probable 3',5'-cyclic phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871945.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
    Conserved Domains (1) summary
    pfam00233
    Location:406647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  8. NM_182147.4NP_871947.1  Probable 3',5'-cyclic phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871947.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
Support Center