cdc-42 Cell division control protein 42 homolog [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cdc-42
Gene description: Cell division control protein 42 homolog
Primary source: WormBase:WBGene00000390
Locus tag: CELE_R07G3.1
See related: AllianceGenome:WB:WBGene00000390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTP binding activity and GTPase activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of clathrin-dependent endocytosis; and positive regulation of nematode male tail tip morphogenesis. Located in several cellular components, including centrosome; perinuclear region of cytoplasm; and recycling endosome. Is integral component of membrane. Is expressed in several structures, including AIY; P8.pa; hermaphrodite gonad; hypodermal cell; and nerve ring. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (7616452..7618245)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Actin and CDC-42 contribute to nuclear migration through constricted spaces in C. elegans.
Title: Actin and CDC-42 contribute to nuclear migration through constricted spaces in C. elegans.
Redox-sensitive CDC-42 clustering promotes wound closure in C. elegans.
Title: Redox-sensitive CDC-42 clustering promotes wound closure in C. elegans.
CDC-42 Interactions with Par Proteins Are Critical for Proper Patterning in Polarization.
Title: CDC-42 Interactions with Par Proteins Are Critical for Proper Patterning in Polarization.
Repression of CDC-42 or SID-3 suppressed trafficking process that requires actin assembly and disassembly.
Title: Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway.
MRCK-1 is required for activation of contractile actomyosin dynamics and elevated cortical tension in the apical cell cortex of endoderm precursor cells. MRCK-1 is apically localized by active Cdc42 at the external, cell-cell contact-free surfaces of apically constricting cells, downstream of cell fate determination mechanisms.
Title: MRCK-1 Drives Apical Constriction in C. elegans by Linking Developmental Patterning to Force Generation.
Junctional CDC-42 controls actin organization and adherens junction protein levels during epithelial morphogenesis.
Title: Cdc42 regulates junctional actin but not cell polarization in the Caenorhabditis elegans epidermis.
RGA-7 is recruited to spatially distinct locations at junctions between adjacent leading cells, where it promotes the accumulation of clusters of activated CDC-42.
Title: Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans.
PAR-3 exists in a dynamic equilibrium between an unclustered form and a clustered form, in response to cortical tension mainly exerted by actomyosin contractility. Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.
Title: Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.
we find that vab-1 lies in the same genetic pathway as cdc-42 and is responsible for polarizing CDC-42 activity to the medial tip. Together, these data establish a previously uncharacterized role for polarized CDC-42, in conjunction with PAR-6, PAR-3 and an Eph receptor(vab-1), during epithelial intercalation.
Title: CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis.
UIG-1, a DH/PH domain containing protein, links a PAT-3/UNC-112 complex to the CDC-42 signaling pathway during muscle formation.
Title: Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R07G3.1 (e-PCR)
- UniSTS:318364

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cell division control protein 42 homolog

NP_495598.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7616452..7618245

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063197.10 → NP_495598.1 Cell division control protein 42 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495598.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91792, Q05062

Conserved Domains (2) summary

smart00174
Location:6 → 179

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family