acdh-12 Acyl CoA DeHydrogenase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: acdh-12
Gene description: Acyl CoA DeHydrogenase
Primary source: WormBase:WBGene00017125
Locus tag: CELE_E04F6.5
See related: AllianceGenome:WB:WBGene00017125
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable fatty-acyl-CoA binding activity and very-long-chain-acyl-CoA dehydrogenase activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See acdh-12 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (7192434..7194770, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors demonstrate for the first time that a deficiency of ACDH-12 affects the formation and function of complex I. They suggest that in Caenorhabditis elegans, ACDH-12 is required for the assembly of the respiratory complex I, but may not be crucial to fatty acid oxidation.
Title: Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans.
Purified very-long-chain acyl-CoA dehydrogenase (12 mg ml(-1)) was successfully crystallized by the hanging-drop vapour-diffusion method under conditions containing 100 mM Tris-HCl pH 8.0, 150 mM sodium chloride, 200 mM magnesium formate and 13% PEG 3350.
Title: Purification, crystallization and preliminary crystallographic analysis of very-long-chain acyl-CoA dehydrogenase from Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

E04F6.5 (e-PCR)
- UniSTS:309529

Homology

Homologs of the acdh-12 gene: The acdh-12 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, and mosquito.
Orthologs

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables very-long-chain-acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Acyl CoA DeHydrogenase

NP_001022062.1

Product from WormBase gene class acdh;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7192434..7194770 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026891.7 → NP_001022062.1 Acyl CoA DeHydrogenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022062.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19057

Conserved Domains (2) summary

cd01161
Location:41 → 449

VLCAD; Very long chain acyl-CoA dehydrogenase

COG1960
Location:61 → 441

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]