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unc-104 Kinesin-like protein unc-104 [ Caenorhabditis elegans ]

Gene ID: 174144, updated on 5-Sep-2019

Summary

Gene symbol
unc-104
Gene description
Kinesin-like protein unc-104
Primary source
WormBase:WBGene00006831
Locus tag
CELE_C52E12.2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See unc-104 in Genome Data Viewer
Location:
chromosome: II
Exon count:
24
Sequence:
Chromosome: II; NC_003280.10 (6994987..7010624)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene UDP-sugar transporter sqv-7 Neighboring gene Lateral Signaling Target

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP-dependent microtubule motor activity, plus-end-directed IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterograde axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterograde synaptic vesicle transport IDA
Inferred from Direct Assay
more info
PubMed 
anterograde synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defecation IMP
Inferred from Mutant Phenotype
more info
PubMed 
feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement IDA
Inferred from Direct Assay
more info
PubMed 
microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
molting cycle, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dense core granule transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
nematode larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of anterior/posterior axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of anterior/posterior axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of anterograde dense core granule transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of growth rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of necrotic cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic growth at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
programmed cell death IEA
Inferred from Electronic Annotation
more info
 
receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventral cord development IGI
Inferred from Genetic Interaction
more info
PubMed 
ventral cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
presynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Kinesin-like protein unc-104
NP_001022041.2
  • Confirmed by transcript evidence
NP_741019.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6994987..7010624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171017.9NP_741019.3  Kinesin-like protein unc-104 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741019.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P23678
    Conserved Domains (8) summary
    smart00129
    Location:3354
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:464563
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:14561558
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:2354
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00169
    Location:14611558
    PH; PH domain
    pfam12423
    Location:781827
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11151214
    DUF3694; Kinesin protein
    pfam16183
    Location:351488
    Kinesin_assoc; Kinesin-associated
  2. NM_001026870.6NP_001022041.2  Kinesin-like protein unc-104 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022041.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P23678
    Conserved Domains (8) summary
    smart00129
    Location:3354
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:464563
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01233
    Location:15001602
    PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
    cd01365
    Location:2354
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00169
    Location:15051602
    PH; PH domain
    pfam12423
    Location:829874
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11621261
    DUF3694; Kinesin protein
    pfam16183
    Location:351488
    Kinesin_assoc; Kinesin-associated
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