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gldi-2 EGF-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174116, updated on 8-Feb-2025

Summary

Official Symbol
gldi-2
Official Full Name
EGF-like domain-containing protein
Primary source
WormBase:WBGene00020481
Locus tag
CELE_T13C2.6
See related
AllianceGenome:WB:WBGene00020481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LRP8 (LDL receptor related protein 8); LDLR (low density lipoprotein receptor); and VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Feb 2025]
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Genomic context

See gldi-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (6783427..6788270)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit A C-terminal domain phosphatase ssup-72 Neighboring gene Transmembrane protein Neighboring gene Clip domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Copper transport protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
EGF-like domain-containing protein
NP_001408275.1
  • Confirmed by transcript evidence
NP_001408276.1
  • Confirmed by transcript evidence
NP_495387.2
  • Confirmed by transcript evidence
NP_872023.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6783427..6788270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062986.6NP_495387.2  EGF-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495387.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZX4
    Conserved Domains (4) summary
    smart00192
    Location:165197
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:604647
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:431461
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:212247
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  2. NM_182223.6NP_872023.2  EGF-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872023.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JP80
    Conserved Domains (4) summary
    smart00192
    Location:167199
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:606649
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:433463
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:214249
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  3. NM_001421348.1NP_001408275.1  EGF-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

  4. NM_001421349.1NP_001408276.1  EGF-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED