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lin-23 F-box/WD repeat-containing protein lin-23 [ Caenorhabditis elegans ]

Gene ID: 174058, updated on 19-Oct-2019

Summary

Gene symbol
lin-23
Gene description
F-box/WD repeat-containing protein lin-23
Primary source
WormBase:WBGene00003009
Locus tag
CELE_K10B2.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See lin-23 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (6371295..6374776)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein;C-type lectin domain-containing protein 88 Neighboring gene Serine carboxypeptidase ctsa-4.1 Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
F-box/WD repeat-containing protein lin-23
NP_001300561.1
  • Confirmed by transcript evidence
NP_001300562.1
  • Confirmed by transcript evidence
NP_001300563.1
  • Confirmed by transcript evidence
NP_495285.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6371295..6374776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062884.6NP_495285.1  F-box/WD repeat-containing protein lin-23 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495285.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09990
    Conserved Domains (4) summary
    smart01028
    Location:4180
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:168515
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:222500
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:225260
    7WD40; WD40 repeat [structural motif]
  2. NM_001313632.2NP_001300561.1  F-box/WD repeat-containing protein lin-23 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUM4
    Conserved Domains (4) summary
    smart01028
    Location:4180
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:168515
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:222500
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:225260
    7WD40; WD40 repeat [structural motif]
  3. NM_001313634.2NP_001300563.1  F-box/WD repeat-containing protein lin-23 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARM6
    Conserved Domains (4) summary
    smart01028
    Location:125
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:113460
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:167445
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:170205
    7WD40; WD40 repeat [structural motif]
  4. NM_001313633.2NP_001300562.1  F-box/WD repeat-containing protein lin-23 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWY7
    Conserved Domains (4) summary
    smart01028
    Location:125
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:113460
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:167445
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:170205
    7WD40; WD40 repeat [structural motif]
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