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fzo-1 Transmembrane GTPase fzo-1 [ Caenorhabditis elegans ]

Gene ID: 173990, updated on 5-Jul-2025
Official Symbol
fzo-1
Official Full Name
Transmembrane GTPase fzo-1
Primary source
WormBase:WBGene00001509
Locus tag
CELE_ZK1248.14
See related
AllianceGenome:WB:WBGene00001509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Involved in mitochondrial fusion. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in intestine; nervous system; pharynx; and tail. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to several human genes including MFN1 (mitofusin 1). [provided by Alliance of Genome Resources, Jul 2025]
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Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (5833328..5836203, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene E3 SUMO-protein ligase NSE2 Neighboring gene Dynein heavy chain 7, axonemal Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene WW domain-containing protein Neighboring gene Beta-catenin-interacting ICAT domain-containing protein

Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome-wide RNAi screen for regulators of UPRmt in Caenorhabditis elegans mutants with defects in mitochondrial fusion. Haeussler S, et al. G3 (Bethesda), 2021 Jul 14. PMID 33784383, Free PMC Article
  2. Erratum: Erratum: Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening in C. elegans. . MicroPubl Biol, 2022. PMID 36636280, Free PMC Article
  3. Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans. Yasuda K, et al. Biochem Biophys Res Commun, 2011 Jan 21. PMID 21144829
  4. Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. Luz AL, et al. Toxicology, 2017 Jul 15. PMID 28602540, Free PMC Article
  5. Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness. Meshnik L, et al. BMC Biol, 2022 Feb 9. PMID 35139855, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans.
    Title: Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans.
  2. Results suggest that the BCL-2-like CED-9 acts through FZO-1 and EAT-3 to promote mitochondrial fusion in response to specific cellular signals.
    Title: The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Transmembrane GTPase fzo-1
NP_495161.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5833328..5836203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062760.8 → NP_495161.1  Transmembrane GTPase fzo-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495161.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23424
    Conserved Domains (2) summary
    cd09912
    Location:101 → 359
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:609 → 767
    Fzo_mitofusin; fzo-like conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23424.1

Gene LinkOut

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