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Mmp14 matrix metallopeptidase 14 (membrane-inserted) [ Mus musculus (house mouse) ]

Gene ID: 17387, updated on 5-Mar-2024

Summary

Official Symbol
Mmp14provided by MGI
Official Full Name
matrix metallopeptidase 14 (membrane-inserted)provided by MGI
Primary source
MGI:MGI:101900
See related
Ensembl:ENSMUSG00000000957 AllianceGenome:MGI:101900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sabe; MMP-X1; MT1-MMP; MT-MMP-1
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]
Expression
Broad expression in ovary adult (RPKM 116.4), limb E14.5 (RPKM 100.7) and 24 other tissues See more
Orthologs
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Genomic context

See Mmp14 in Genome Data Viewer
Location:
14 C2; 14 27.79 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54669055..54679913)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54431598..54442456)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene oxidase assembly 1-like Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 Neighboring gene STARR-seq mESC enhancer starr_36728 Neighboring gene STARR-positive B cell enhancer ABC_E3115 Neighboring gene STARR-seq mESC enhancer starr_36729 Neighboring gene STARR-seq mESC enhancer starr_36730 Neighboring gene STARR-seq mESC enhancer starr_36733 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene STARR-positive B cell enhancer mm9_chr14:55067911-55068211 Neighboring gene STARR-seq mESC enhancer starr_36736 Neighboring gene predicted gene, 24424 Neighboring gene STARR-positive B cell enhancer ABC_E8559 Neighboring gene STARR-positive B cell enhancer ABC_E5436 Neighboring gene low-density lipoprotein receptor-related protein 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (13)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within bone development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chondrocyte proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within collagen catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within craniofacial suture morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endochondral ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tissue remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within zymogen activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zymogen activation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in macropinosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
matrix metalloproteinase-14
Names
Membrane type 1-MMP
matrix metalloproteinase 14 (membrane-inserted)
membrane-type-1 matrix metalloproteinase
type 1 matrix metalloprotease 14
NP_032634.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008608.4NP_032634.3  matrix metalloproteinase-14 preproprotein

    See identical proteins and their annotated locations for NP_032634.3

    Status: REVIEWED

    Source sequence(s)
    AC206013, AK165014, W75261
    Consensus CDS
    CCDS36922.1
    UniProtKB/Swiss-Prot
    O08645, O35369, P53690, Q8BTX2
    UniProtKB/TrEMBL
    Q3TQH0
    Related
    ENSMUSP00000087119.5, ENSMUST00000089688.6
    Conserved Domains (5) summary
    cd00094
    Location:316508
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:118284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:118284
    Peptidase_M10; Matrixin
    pfam01471
    Location:3688
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:560582
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54669055..54679913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)