U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mmp11 matrix metallopeptidase 11 [ Mus musculus (house mouse) ]

Gene ID: 17385, updated on 12-May-2024

Summary

Official Symbol
Mmp11provided by MGI
Official Full Name
matrix metallopeptidase 11provided by MGI
Primary source
MGI:MGI:97008
See related
Ensembl:ENSMUSG00000000901 AllianceGenome:MGI:97008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ST3; SL-3; Stmy3; MMP-11
Summary
This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in ovary adult (RPKM 143.8), limb E14.5 (RPKM 82.7) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mmp11 in Genome Data Viewer
Location:
10 C1; 10 38.62 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75759056..75768336, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75923221..75932502, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E193 Neighboring gene Der1-like domain family, member 3 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E8863 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene STARR-seq mESC enhancer starr_27166 Neighboring gene predicted gene 867 Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene 60S ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular matrix IC
Inferred by Curator
more info
PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
stromelysin-3
Names
matrix metalloproteinase 11
stromelysin 3
NP_001293113.1
NP_032632.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306184.1NP_001293113.1  stromelysin-3 preproprotein

    See identical proteins and their annotated locations for NP_001293113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK165778, BY100700, CD742452
    Consensus CDS
    CCDS23937.1
    UniProtKB/Swiss-Prot
    Q02853
    UniProtKB/TrEMBL
    Q3UQT3, Q7TPW7
    Related
    ENSMUSP00000112940.2, ENSMUST00000120281.8
    Conserved Domains (3) summary
    cd00094
    Location:295484
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:108262
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:108262
    Peptidase_M10; Matrixin
  2. NM_008606.3NP_032632.1  stromelysin-3 preproprotein

    See identical proteins and their annotated locations for NP_032632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK142169, BY100700, CD742452
    Consensus CDS
    CCDS23937.1
    UniProtKB/Swiss-Prot
    Q02853
    UniProtKB/TrEMBL
    Q3UQT3, Q7TPW7
    Related
    ENSMUSP00000000924.7, ENSMUST00000000924.13
    Conserved Domains (3) summary
    cd00094
    Location:295484
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:108262
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:108262
    Peptidase_M10; Matrixin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75759056..75768336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)