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Mme membrane metallo endopeptidase [ Mus musculus (house mouse) ]

Gene ID: 17380, updated on 12-May-2024

Summary

Official Symbol
Mmeprovided by MGI
Official Full Name
membrane metallo endopeptidaseprovided by MGI
Primary source
MGI:MGI:97004
See related
Ensembl:ENSMUSG00000027820 AllianceGenome:MGI:97004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NEP; SFE; CD10; CALLA; 6030454K05Rik
Summary
Enables peptidase activity. Involved in amyloid-beta clearance; positive regulation of long-term synaptic potentiation; and sensory perception of pain. Acts upstream of or within amyloid-beta metabolic process. Located in several cellular components, including dendrite; neuron projection terminus; and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and mammary gland. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 8.6), kidney adult (RPKM 7.9) and 18 other tissues See more
Orthologs
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Genomic context

See Mme in Genome Data Viewer
Location:
3 E1; 3 29.97 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63202632..63291134)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63295211..63383713)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 4 (mitochondrial) pseudogene Neighboring gene STARR-seq mESC enhancer starr_07827 Neighboring gene STARR-seq mESC enhancer starr_07828 Neighboring gene STARR-seq mESC enhancer starr_07829 Neighboring gene predicted gene, 40064 Neighboring gene predicted gene, 57709 Neighboring gene STARR-seq mESC enhancer starr_07831 Neighboring gene STARR-seq mESC enhancer starr_07832 Neighboring gene predicted gene, 34240 Neighboring gene small transmembrane regulator of ion transport 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cardiolipin binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables exopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables oligopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amyloid-beta clearance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid-beta clearance by cellular catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amyloid-beta metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in creatinine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide processing ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substance P catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neprilysin
Names
atriopeptidase
common acute lymphoblastic leukemia antigen
enkephalinase
neutral endopeptidase 24.11
skin fibroblast elastase
NP_001276391.1
NP_001276392.1
NP_001344264.1
NP_032630.2
XP_006501161.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289462.1NP_001276391.1  neprilysin

    See identical proteins and their annotated locations for NP_001276391.1

    Status: VALIDATED

    Source sequence(s)
    AC121840, AK031446, AK076908, BY145991
    Consensus CDS
    CCDS17381.1
    UniProtKB/Swiss-Prot
    Q61391, Q6NXX5, Q8K251
    Related
    ENSMUSP00000141544.2, ENSMUST00000194150.6
    Conserved Domains (1) summary
    cd08662
    Location:77748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  2. NM_001289463.1NP_001276392.1  neprilysin

    See identical proteins and their annotated locations for NP_001276392.1

    Status: VALIDATED

    Source sequence(s)
    AC121840, AC121993, AK031446, AK033824
    Consensus CDS
    CCDS17381.1
    UniProtKB/Swiss-Prot
    Q61391, Q6NXX5, Q8K251
    Related
    ENSMUSP00000029400.2, ENSMUST00000029400.7
    Conserved Domains (1) summary
    cd08662
    Location:77748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  3. NM_001357335.1NP_001344264.1  neprilysin

    Status: VALIDATED

    Source sequence(s)
    AC121840, AC121993
    Consensus CDS
    CCDS17381.1
    UniProtKB/Swiss-Prot
    Q61391, Q6NXX5, Q8K251
    Conserved Domains (1) summary
    cd08662
    Location:77748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
  4. NM_008604.4NP_032630.2  neprilysin

    See identical proteins and their annotated locations for NP_032630.2

    Status: VALIDATED

    Source sequence(s)
    AC121840, AK031446
    Consensus CDS
    CCDS17381.1
    UniProtKB/Swiss-Prot
    Q61391, Q6NXX5, Q8K251
    Related
    ENSMUSP00000142205.2, ENSMUST00000194134.6
    Conserved Domains (1) summary
    cd08662
    Location:77748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    63202632..63291134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501098.4XP_006501161.1  neprilysin isoform X1

    See identical proteins and their annotated locations for XP_006501161.1

    UniProtKB/Swiss-Prot
    Q61391, Q6NXX5, Q8K251
    Conserved Domains (1) summary
    cd08662
    Location:77748
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I