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Mki67 antigen identified by monoclonal antibody Ki 67 [ Mus musculus (house mouse) ]

Gene ID: 17345, updated on 25-Jan-2022

Summary

Official Symbol
Mki67provided by MGI
Official Full Name
antigen identified by monoclonal antibody Ki 67provided by MGI
Primary source
MGI:MGI:106035
See related
Ensembl:ENSMUSG00000031004 AllianceGenome:MGI:106035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ki67; Ki-67; D630048A14Rik
Summary
Predicted to enable protein C-terminus binding activity. Involved in regulation of chromatin organization. Acts upstream of or within cholangiocyte proliferation; hepatocyte proliferation; and meiotic cell cycle. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in liver E14 (RPKM 21.8), liver E14.5 (RPKM 14.9) and 8 other tissues See more
Orthologs
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Genomic context

See Mki67 in Genome Data Viewer
Location:
7; 7 F3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (135291513..135318286, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (135689784..135716450, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (142881471..142908062, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, E Neighboring gene microRNA 1962 Neighboring gene RIKEN cDNA 5830432E09 gene Neighboring gene predicted gene, 36431 Neighboring gene RIKEN cDNA 6330420H09 gene Neighboring gene predicted gene 45241

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with condensed chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
proliferation marker protein Ki-67
Names
antigen KI-67 homolog
antigen Ki67 homolog
antigen identified by monoclonal antibody Ki-67 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081117.2NP_001074586.2  proliferation marker protein Ki-67

    Status: VALIDATED

    Source sequence(s)
    AC123047, AK052772, AK143677, BC053453
    Consensus CDS
    CCDS52421.1
    UniProtKB/Swiss-Prot
    E9PVX6
    Related
    ENSMUSP00000033310.8, ENSMUST00000033310.9
    Conserved Domains (4) summary
    COG1716
    Location:1192
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:7101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08065
    Location:11091216
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:463529
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    135291513..135318286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507413.5XP_006507476.1  proliferation marker protein Ki-67 isoform X2

    Conserved Domains (3) summary
    cd00060
    Location:7101
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08065
    Location:18541964
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:143184
    PP1_bind; Protein phosphatase 1 binding
  2. XM_036152742.1XP_036008635.1  proliferation marker protein Ki-67 isoform X1

    Conserved Domains (2) summary
    pfam08065
    Location:20302140
    K167R; K167R (NUC007) repeat
    pfam15276
    Location:318360
    PP1_bind; Protein phosphatase 1 binding
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