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pole-1 DNA polymerase epsilon catalytic subunit [ Caenorhabditis elegans ]

Gene ID: 173368, updated on 23-Nov-2023

Summary

Gene symbol
pole-1
Gene description
DNA polymerase epsilon catalytic subunit
Primary source
WormBase:WBGene00009368
Locus tag
CELE_F33H2.5
See related
AllianceGenome:WB:WBGene00009368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and single-stranded DNA 3'-5' exodeoxyribonuclease activity. Predicted to be involved in DNA metabolic process and mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of epsilon DNA polymerase complex. Is expressed in intestine and seam cell. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See pole-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (15005603..15013904, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene TEP (ThiolEster containing Protein) Neighboring gene Protein mtd-1 Neighboring gene TPR_REGION domain-containing protein Neighboring gene DNA helicase

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA 3'-5' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
located_in cellular anatomical entity IEA
Inferred from Electronic Annotation
more info
 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of epsilon DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA polymerase epsilon catalytic subunit
NP_493616.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    15005603..15013904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061215.6NP_493616.1  DNA polymerase epsilon catalytic subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493616.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62218
    Conserved Domains (4) summary
    cd05779
    Location:253455
    DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
    cd05535
    Location:5161132
    POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
    COG0417
    Location:691144
    PolB; DNA polymerase elongation subunit (family B) [Replication, recombination and repair]
    pfam08490
    Location:14701869
    DUF1744; Domain of unknown function (DUF1744)