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dnj-12 DNaJ domain (prokaryotic heat shock protein) [ Caenorhabditis elegans ]

Gene ID: 173341, updated on 2-Dec-2025
Official Symbol
dnj-12
Official Full Name
DNaJ domain (prokaryotic heat shock protein)
Primary source
WormBase:WBGene00001030
Locus tag
CELE_F39B2.10
See related
AllianceGenome:WB:WBGene00001030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ATPase activator activity. Predicted to be involved in protein refolding. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; pharynx; and reproductive system. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1) and DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Jul 2025]
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Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (14757063..14758787)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box/LRR-repeat protein Neighboring gene Metaxin-1 homolog Neighboring gene Transmembrane protein 107 Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein eS26

Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response. Joshi P, et al. Commun Biol, 2021 Jul 7. PMID 34234268, Free PMC Article
  2. In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Kirstein J, et al. Aging Cell, 2017 Dec. PMID 29024389, Free PMC Article
  3. Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90. Schmauder L, et al. Sci Rep, 2021 Nov 1. PMID 34725424, Free PMC Article
  4. Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nillegoda NB, et al. Nature, 2015 Aug 13. PMID 26245380, Free PMC Article
  5. head-bent resistant Hsc70 variants show reduced Hsp40 affinity and altered protein folding activity. Papsdorf K, et al. Sci Rep, 2019 Aug 16. PMID 31420580, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals.
    Title: Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNaJ domain (prokaryotic heat shock protein)
NP_493570.1
  • Product from WormBase gene class dnj;
    Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14757063..14758787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061169.8 → NP_493570.1  DNaJ domain (prokaryotic heat shock protein)

    See identical proteins and their annotated locations for NP_493570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45502
    Conserved Domains (4) summary
    cd10719
    Location:136 → 201
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:200 → 334
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:2 → 401
    PTZ00037; DnaJ_C chaperone protein; Provisional
    pfam00226
    Location:7 → 65
    DnaJ; DnaJ domain
Nucleotide Protein
Heading Accession and Version

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