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vab-10 GAR domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173058, updated on 19-Oct-2019

Summary

Gene symbol
vab-10
Gene description
GAR domain-containing protein
Primary source
WormBase:WBGene00006876
Locus tag
CELE_ZK1151.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See vab-10 in Genome Data Viewer
Location:
chromosome: I
Exon count:
33
Sequence:
Chromosome: I; NC_003279.8 (11747424..11792118, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene tRNA

Bibliography

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intermediate filament cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
hemidesmosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemidesmosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
intracellular organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GAR domain-containing protein
NP_001021853.1
  • Confirmed by transcript evidence
NP_001021854.1
  • Confirmed by transcript evidence
NP_001021855.1
  • Confirmed by transcript evidence
NP_001021856.1
  • Partially confirmed by transcript evidence
NP_001021857.1
  • Partially confirmed by transcript evidence
NP_001021858.1
  • Partially confirmed by transcript evidence
NP_001021859.1
  • Confirmed by transcript evidence
NP_001040721.1
  • Partially confirmed by transcript evidence
NP_001122565.1
  • Partially confirmed by transcript evidence
NP_001335519.1
  • Confirmed by transcript evidence
NP_001335520.1
  • Confirmed by transcript evidence
NP_001335521.1
  • Partially confirmed by transcript evidence
NP_001335522.1
  • Partially confirmed by transcript evidence
NP_001335523.1
  • Confirmed by transcript evidence
NP_001335524.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11747424..11792118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348620.2NP_001335520.1  GAR domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYR7
    Conserved Domains (7) summary
    smart00243
    Location:45964668
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    COG5069
    Location:40284
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:36393844
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02488
    Location:8751089
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:709753
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:14902280
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:41124531
    Neuromodulin_N; Gap junction protein N-terminal region
  2. NM_001348621.2NP_001335519.1  GAR domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYN9
    Conserved Domains (7) summary
    smart00243
    Location:47094781
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    COG5069
    Location:40284
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:37523957
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02488
    Location:9881202
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:822866
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:16032393
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:42254644
    Neuromodulin_N; Gap junction protein N-terminal region
  3. NM_001026683.3NP_001021854.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021854.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFM4
    Conserved Domains (7) summary
    smart00243
    Location:47214793
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:537631
    SPEC; Spectrin repeats
    COG1196
    Location:22052984
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:40142
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:37643969
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:16152405
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:44194620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. NM_001348622.2NP_001335522.1  GAR domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYN7
    Conserved Domains (8) summary
    smart00243
    Location:47234795
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:551645
    SPEC; Spectrin repeats
    cd00176
    Location:37663971
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:307413
    CH; Calponin homology (CH) domain
    cl02488
    Location:10021216
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:836880
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:16172407
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:42394658
    Neuromodulin_N; Gap junction protein N-terminal region
  5. NM_001348623.2NP_001335521.1  GAR domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYP3
    Conserved Domains (8) summary
    smart00243
    Location:48364908
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:664758
    SPEC; Spectrin repeats
    cd00176
    Location:38794084
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:307413
    CH; Calponin homology (CH) domain
    cl02488
    Location:11151329
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:949993
    SH3; Src Homology 3 domain superfamily
    cl25732
    Location:17302520
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:43524771
    Neuromodulin_N; Gap junction protein N-terminal region
  6. NM_001348624.2NP_001335523.1  GAR domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYQ0
    Conserved Domains (5) summary
    smart00243
    Location:33413413
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00176
    Location:23842589
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02488
    Location:17231934
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl25732
    Location:2351025
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:28573276
    Neuromodulin_N; Gap junction protein N-terminal region
  7. NM_001348625.2NP_001335524.1  GAR domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYN2
    Conserved Domains (5) summary
    smart00243
    Location:32273299
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00176
    Location:22702475
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02488
    Location:16091820
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl25732
    Location:121911
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:27433162
    Neuromodulin_N; Gap junction protein N-terminal region
  8. NM_001026688.4NP_001021859.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021859.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECG5
    Conserved Domains (6) summary
    smart00243
    Location:41874259
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:537631
    SPEC; Spectrin repeats
    cd00014
    Location:40142
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:32193424
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:16152382
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:25582769
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  9. NM_001026684.4NP_001021855.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021855.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDD3
    Conserved Domains (7) summary
    smart00243
    Location:47324804
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:537631
    SPEC; Spectrin repeats
    COG1196
    Location:22052984
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:40142
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:37643969
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:16152405
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:44194620
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  10. NM_001026686.4NP_001021857.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECG8
    Conserved Domains (8) summary
    smart00150
    Location:424518
    SPEC; Spectrin repeats
    smart00250
    Location:14771514
    PLEC; Plectin repeat
    cd00014
    Location:40142
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:520693
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:180281
    CH; Calponin homology (CH) domain
    pfam00681
    Location:31943232
    Plectin; Plectin repeat
    cl02488
    Location:9991240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:708753
    SH3; Src Homology 3 domain superfamily
  11. NM_001047256.4NP_001040721.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040721.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECP9
    Conserved Domains (7) summary
    smart00150
    Location:537631
    SPEC; Spectrin repeats
    smart00250
    Location:15781615
    PLEC; Plectin repeat
    cd00014
    Location:40142
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:633806
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:180281
    CH; Calponin homology (CH) domain
    pfam00681
    Location:32953333
    Plectin; Plectin repeat
    cl17036
    Location:821866
    SH3; Src Homology 3 domain superfamily
  12. NM_001026687.4NP_001021858.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021858.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFK7
    Conserved Domains (8) summary
    smart00150
    Location:537631
    SPEC; Spectrin repeats
    smart00250
    Location:14761513
    PLEC; Plectin repeat
    cd00014
    Location:40142
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:633806
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:180281
    CH; Calponin homology (CH) domain
    pfam00681
    Location:31933231
    Plectin; Plectin repeat
    cl02488
    Location:11121353
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:821866
    SH3; Src Homology 3 domain superfamily
  13. NM_001026682.3NP_001021853.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021853.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEC4
    Conserved Domains (7) summary
    smart00150
    Location:537631
    SPEC; Spectrin repeats
    smart00250
    Location:15901627
    PLEC; Plectin repeat
    cd00014
    Location:40142
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:633806
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:180281
    CH; Calponin homology (CH) domain
    pfam00681
    Location:33073345
    Plectin; Plectin repeat
    cl17036
    Location:821866
    SH3; Src Homology 3 domain superfamily
  14. NM_001026685.2NP_001021856.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFW2
    Conserved Domains (7) summary
    smart00150
    Location:506600
    SPEC; Spectrin repeats
    smart00250
    Location:15591596
    PLEC; Plectin repeat
    cd00014
    Location:40116
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:602775
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:149250
    CH; Calponin homology (CH) domain
    pfam00681
    Location:32763314
    Plectin; Plectin repeat
    cl17036
    Location:790835
    SH3; Src Homology 3 domain superfamily
  15. NM_001129093.3NP_001122565.1  GAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFD1
    Conserved Domains (4) summary
    smart00150
    Location:664758
    SPEC; Spectrin repeats
    cd00014
    Location:307413
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:760933
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17036
    Location:949993
    SH3; Src Homology 3 domain superfamily
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