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hmr-1 Cadherin-related hmr-1 [ Caenorhabditis elegans ]

Gene ID: 173007, updated on 18-Sep-2024

Summary

Official Symbol
hmr-1
Official Full Name
Cadherin-related hmr-1
Primary source
WormBase:WBGene00001980
Locus tag
CELE_W02B9.1
See related
AllianceGenome:WB:WBGene00001980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction. Is spanning component of plasma membrane. Part of catenin complex. Is expressed in several structures, including distal tip cell; hypodermis; motor neurons; nerve ring; and neuroblasts. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See hmr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
31
Sequence:
Chromosome: I; NC_003279.8 (11075758..11134667, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene THAP-type domain-containing protein Neighboring gene pseudo Neighboring gene Ig-like_bact domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables delta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in apical constriction involved in gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
part_of catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of catenin complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in distal dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Cadherin-related hmr-1
NP_001021650.1
  • Confirmed by transcript evidence
NP_001251561.1
  • Confirmed by transcript evidence
NP_001368105.1
  • Confirmed by transcript evidence
NP_001379266.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11075758..11134667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026479.4NP_001021650.1  Cadherin-related hmr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021650.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2MZC5, H2FLJ9, H2FLK0, O44327, Q967F4
    Conserved Domains (5) summary
    cd11304
    Location:647742
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:22502283
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:22862459
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01049
    Location:28122919
    Cadherin_C; Cadherin cytoplasmic region
    cl22861
    Location:25332679
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. NM_001392947.1NP_001379266.1  Cadherin-related hmr-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (5) summary
    cd11304
    Location:127217
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:600632
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:635808
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01049
    Location:11611268
    Cadherin_C; Cadherin cytoplasmic region
    cl22861
    Location:8821028
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  3. NM_001264632.3NP_001251561.1  Cadherin-related hmr-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251561.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q967F4
    Conserved Domains (5) summary
    cd11304
    Location:26129
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:395427
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:430603
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01049
    Location:9561063
    Cadherin_C; Cadherin cytoplasmic region
    cl22861
    Location:677823
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  4. NM_001381216.1NP_001368105.1  Cadherin-related hmr-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (4) summary
    cd00054
    Location:265297
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:300473
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01049
    Location:826933
    Cadherin_C; Cadherin cytoplasmic region
    cl22861
    Location:547693
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...