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daf-16 Forkhead box protein O [ Caenorhabditis elegans ]

Gene ID: 172981, updated on 19-Mar-2019

Summary

Gene symbol
daf-16
Gene description
Forkhead box protein O
Primary source
WormBase:WBGene00000912
Locus tag
CELE_R13H8.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See daf-16 in Genome Data Viewer
Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (10750498..10775050)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene L-Fucosyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glutathione PeroXidase

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
DEAD/H-box RNA helicase binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aging IDA
Inferred from Direct Assay
more info
PubMed 
aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
dauer larval development IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan IDA
Inferred from Direct Assay
more info
PubMed 
determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat acclimation IGI
Inferred from Genetic Interaction
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
nematode larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuromuscular synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic growth at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA-templated transcription in response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle process IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of dauer entry IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid storage IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synaptic growth at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to UV IDA
Inferred from Direct Assay
more info
PubMed 
response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
short-term memory IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Forkhead box protein O
NP_001021593.1
  • Confirmed by transcript evidence
NP_001021594.1
  • Confirmed by transcript evidence
NP_001021595.1
  • Confirmed by transcript evidence
NP_001021596.1
  • Confirmed by transcript evidence
NP_001021597.1
  • Confirmed by transcript evidence
NP_001021598.2
  • Confirmed by transcript evidence
NP_001251490.1
  • Confirmed by transcript evidence
NP_001251492.1
  • Confirmed by transcript evidence
NP_001300402.1
  • Confirmed by transcript evidence
NP_001300403.1
  • Confirmed by transcript evidence
NP_001300433.1
  • Confirmed by transcript evidence
NP_001300434.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10750498..10775050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001264561.1NP_001251490.1  Forkhead box protein O [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251490.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16850
    Conserved Domains (1) summary
    cd00059
    Location:175255
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  2. NM_001026427.4NP_001021598.2  Forkhead box protein O [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021598.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16850
    Conserved Domains (1) summary
    cd00059
    Location:151231
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  3. NM_001313473.1NP_001300402.1  Forkhead box protein O [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWG6
    Conserved Domains (1) summary
    cd00059
    Location:149229
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  4. NM_001026425.3NP_001021596.1  Forkhead box protein O [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021596.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16850
    Conserved Domains (1) summary
    cd00059
    Location:121201
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  5. NM_001313474.1NP_001300403.1  Forkhead box protein O [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR63
    Conserved Domains (1) summary
    cd00059
    Location:119199
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  6. NM_001026424.4NP_001021595.1  Forkhead box protein O [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021595.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16850
    Conserved Domains (1) summary
    cd00059
    Location:144224
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  7. NM_001026423.4NP_001021594.1  Forkhead box protein O [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021594.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16850
    Conserved Domains (1) summary
    cd00059
    Location:142222
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  8. NM_001313504.1NP_001300433.1  Forkhead box protein O [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR95
    Conserved Domains (1) summary
    cd00059
    Location:41121
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  9. NM_001313505.1NP_001300434.1  Forkhead box protein O [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ATP5
    Conserved Domains (1) summary
    cd00059
    Location:39119
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  10. NM_001026422.4NP_001021593.1  Forkhead box protein O [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021593.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16850
    Conserved Domains (1) summary
    smart00339
    Location:164249
    FH; FORKHEAD
  11. NM_001264563.1NP_001251492.1  Forkhead box protein O [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251492.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16850
    Conserved Domains (1) summary
    cl00061
    Location:943
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  12. NM_001026426.2NP_001021597.1  Forkhead box protein O [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021597.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16850
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