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Mertk MER proto-oncogene tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 17289, updated on 26-Sep-2022

Summary

Official Symbol
Mertkprovided by MGI
Official Full Name
MER proto-oncogene tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:96965
See related
Ensembl:ENSMUSG00000014361 AllianceGenome:MGI:96965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eyk; Mer; Nyk; nmf12
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including animal organ development; neutrophil clearance; and protein kinase B signaling. Predicted to be located in several cellular components, including extracellular space; photoreceptor outer segment; and rhabdomere. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and retina. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 4.8), kidney adult (RPKM 4.4) and 28 other tissues See more
Orthologs
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Genomic context

See Mertk in Genome Data Viewer
Location:
2; 2 F1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128540835..128645082)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128698915..128803162)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene anaphase promoting complex subunit 1 Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene transmembrane protein 87B Neighboring gene fibulin 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic cell clearance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of lymphocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of leukocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of lymphocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neutrophil clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within secretion by cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vagina development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase Mer
Names
Tyro 12
c-mer proto-oncogene tyrosine kinase
proto-oncogene c-Mer
proto-oncogene tyrosine-protein kinase Mer
receptor tyrosine kinase MerTK
NP_032613.1
XP_006498923.1
XP_036014911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008587.2NP_032613.1  tyrosine-protein kinase Mer precursor

    See identical proteins and their annotated locations for NP_032613.1

    Status: VALIDATED

    Source sequence(s)
    AK171320, AL808104, U21301
    Consensus CDS
    CCDS16716.1
    UniProtKB/Swiss-Prot
    Q60805, Q62194
    Related
    ENSMUSP00000014505.5, ENSMUST00000014505.5
    Conserved Domains (6) summary
    cd05749
    Location:194274
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00410
    Location:198275
    IG_like; Immunoglobulin like
    cd00063
    Location:279373
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:574857
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:97177
    ig; Immunoglobulin domain
    pfam07714
    Location:582849
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    128540835..128645082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498860.4XP_006498923.1  tyrosine-protein kinase Mer isoform X1

    Conserved Domains (4) summary
    cd05749
    Location:205285
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    smart00409
    Location:106199
    IG; Immunoglobulin
    cd00063
    Location:290384
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:585868
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
  2. XM_036159018.1XP_036014911.1  tyrosine-protein kinase Mer isoform X2

    Conserved Domains (1) summary
    cd14204
    Location:78361
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer