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Mertk MER proto-oncogene tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 17289, updated on 21-May-2019

Summary

Official Symbol
Mertkprovided by MGI
Official Full Name
MER proto-oncogene tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:96965
See related
Ensembl:ENSMUSG00000014361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eyk; Mer; Nyk; nmf12
Expression
Ubiquitous expression in lung adult (RPKM 4.8), kidney adult (RPKM 4.4) and 28 other tissues See more
Orthologs

Genomic context

See Mertk in Genome Data Viewer
Location:
2; 2 F1
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (128698997..128803162)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (128524733..128627923)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 1 Neighboring gene predicted gene, 39931 Neighboring gene transmembrane protein 87B Neighboring gene fibulin 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of leukocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lymphocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
secretion by cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vagina development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rhabdomere ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein kinase Mer
Names
Tyro 12
c-mer proto-oncogene tyrosine kinase
proto-oncogene c-Mer
proto-oncogene tyrosine-protein kinase Mer
receptor tyrosine kinase MerTK
NP_032613.1
XP_006498923.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008587.2NP_032613.1  tyrosine-protein kinase Mer precursor

    See identical proteins and their annotated locations for NP_032613.1

    Status: VALIDATED

    Source sequence(s)
    AK171320, AL808104, U21301
    Consensus CDS
    CCDS16716.1
    UniProtKB/Swiss-Prot
    Q60805
    Related
    ENSMUSP00000014505.4, ENSMUST00000014505.4
    Conserved Domains (6) summary
    cd05749
    Location:194274
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00410
    Location:198275
    IG_like; Immunoglobulin like
    cd00063
    Location:279373
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:574857
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:97177
    ig; Immunoglobulin domain
    pfam07714
    Location:582849
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    128698997..128803162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498860.3XP_006498923.1  tyrosine-protein kinase Mer isoform X1

    Conserved Domains (6) summary
    cd05749
    Location:205285
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00410
    Location:209286
    IG_like; Immunoglobulin like
    cd00063
    Location:290384
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14204
    Location:585868
    PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
    pfam00047
    Location:108188
    ig; Immunoglobulin domain
    pfam07714
    Location:593860
    Pkinase_Tyr; Protein tyrosine kinase
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