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Men1 multiple endocrine neoplasia 1 [ Mus musculus (house mouse) ]

Gene ID: 17283, updated on 8-Feb-2024

Summary

Official Symbol
Men1provided by MGI
Official Full Name
multiple endocrine neoplasia 1provided by MGI
Primary source
MGI:MGI:1316736
See related
Ensembl:ENSMUSG00000024947 AllianceGenome:MGI:1316736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in histone H3-K4 methylation. Acts upstream of or within several processes, including osteoblast development; positive regulation of macromolecule metabolic process; and regulation of osteoblast differentiation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 36.9), ovary adult (RPKM 36.7) and 28 other tissues See more
Orthologs
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Genomic context

See Men1 in Genome Data Viewer
Location:
19 4.45 cM; 19 A
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6385009..6390924)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6334979..6340894)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene EH-domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_45427 Neighboring gene predicted gene, 52380 Neighboring gene STARR-positive B cell enhancer ABC_E5682 Neighboring gene CDC42 binding protein kinase gamma Neighboring gene STARR-positive B cell enhancer ABC_E11670 Neighboring gene STARR-positive B cell enhancer ABC_E3239 Neighboring gene STARR-positive B cell enhancer ABC_E11015 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene predicted gene, 57665

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (12)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables Y-form DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Y-form DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of fibroblast apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal process involved in female pregnancy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of organ growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of type B pancreatic cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of organ growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoblast development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within osteoblast development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoblast fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to transforming growth factor beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in type B pancreatic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of type B pancreatic cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1/2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168488.1NP_001161960.1  menin isoform a

    See identical proteins and their annotated locations for NP_001161960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC127556, AF016398, BY619391, CF170561
    Consensus CDS
    CCDS50366.1
    UniProtKB/TrEMBL
    A0A0R4J1I3, F8WHD9
    Related
    ENSMUSP00000109130.4, ENSMUST00000113502.10
    Conserved Domains (2) summary
    cd14456
    Location:9464
    Menin; Scaffolding protein menin encoded by the MEN1 gene
    pfam05053
    Location:8615
    Menin; Menin
  2. NM_001168489.1NP_001161961.1  menin isoform b

    See identical proteins and their annotated locations for NP_001161961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC127556, AF016398, BY619391
    Consensus CDS
    CCDS29502.1
    UniProtKB/Swiss-Prot
    O88559, Q3U491, Q8CI72, Q91UZ7
    UniProtKB/TrEMBL
    F8WHD9
    Related
    ENSMUSP00000078306.6, ENSMUST00000079327.12
    Conserved Domains (2) summary
    cd14456
    Location:3458
    Menin; Scaffolding protein menin encoded by the MEN1 gene
    pfam05053
    Location:2609
    Menin; Menin
  3. NM_001168490.1NP_001161962.1  menin isoform c

    See identical proteins and their annotated locations for NP_001161962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
    Source sequence(s)
    AF016398, BY319905, BY619391, CX568988
    Consensus CDS
    CCDS50367.1
    UniProtKB/TrEMBL
    F8WHD9
    Related
    ENSMUSP00000077272.6, ENSMUST00000078137.12
    Conserved Domains (2) summary
    cd14456
    Location:3390
    Menin; Scaffolding protein menin encoded by the MEN1 gene
    pfam05053
    Location:2554
    Menin; Menin
  4. NM_008583.2NP_032609.1  menin isoform b

    See identical proteins and their annotated locations for NP_032609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AF016398, BY319905, BY619391, CX568988
    Consensus CDS
    CCDS29502.1
    UniProtKB/Swiss-Prot
    O88559, Q3U491, Q8CI72, Q91UZ7
    UniProtKB/TrEMBL
    F8WHD9
    Related
    ENSMUSP00000058149.9, ENSMUST00000056391.15
    Conserved Domains (2) summary
    cd14456
    Location:3458
    Menin; Scaffolding protein menin encoded by the MEN1 gene
    pfam05053
    Location:2609
    Menin; Menin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6385009..6390924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)