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NQO1 NAD(P)H quinone dehydrogenase 1 [ Homo sapiens (human) ]

Gene ID: 1728, updated on 27-Nov-2024

Summary

Official Symbol
NQO1provided by HGNC
Official Full Name
NAD(P)H quinone dehydrogenase 1provided by HGNC
Primary source
HGNC:HGNC:2874
See related
Ensembl:ENSG00000181019 MIM:125860; AllianceGenome:HGNC:2874
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTD; QR1; DHQU; DIA4; NMOR1; NMORI
Summary
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 136.7), gall bladder (RPKM 67.3) and 11 other tissues See more
Orthologs
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Genomic context

See NQO1 in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (69709401..69726560, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (75511583..75528719, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69743304..69760463, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:69599594-69599770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7664 Neighboring gene nuclear factor of activated T cells 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11043 Neighboring gene MPRA-validated peak2631 silencer Neighboring gene small nucleolar RNA, C/D box 13H Neighboring gene ReSE screen-validated silencer GRCh37_chr16:69753551-69753732 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:69760025-69761224 Neighboring gene NQO1 divergent transcript Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69787875-69788498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:69788499-69789121 Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene non-POU domain containing, octamer-binding pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 significantly upregulates Nrf2 in human astrocytes and is associated with increased levels of key antioxidant defensive enzymes Hemoxygenase (HO-1) and NAD(P)H dehydrogenase quinone1 (Nqo1) PubMed
Rev rev HIV-1 Rev downregulates the expression of NQO1 which indirectly induces the degradation of Tat PubMed
Tat tat HIV-1 Tat upregulates NQO1, CAT, SOD1, SOD2, and HMOX1 (HO1) mRNA levels in SH-SY5Y cells PubMed
tat HIV-1 Tat is stabilized by NQO1, inhibitor of 20S poteasome PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in NADH oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in NADPH oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell redox homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to metal ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ferroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nitric oxide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in removal of superoxide radicals IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to L-glutamine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to alkaloid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to carbohydrate IEA
Inferred from Electronic Annotation
more info
 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to flavonoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen sulfide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to testosterone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to tetrachloromethane IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance TAS
Traceable Author Statement
more info
PubMed 
involved_in synaptic transmission, cholinergic TAS
Traceable Author Statement
more info
PubMed 
involved_in ubiquinone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vitamin E metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vitamin K metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NAD(P)H dehydrogenase [quinone] 1
Names
DT-diaphorase
NAD(P)H dehydrogenase, quinone 1
NAD(P)H-quinone oxidoreductase
NAD(P)H:Quinone acceptor oxidoreductase type 1
NAD(P)H:menadione oxidoreductase 1
NAD(P)H:quinone oxidoreductase 1
NAD(P)H:quinone oxireductase
azoreductase
diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
diaphorase-4
dioxin-inducible 1
menadione reductase
phylloquinone reductase
quinone reductase 1
NP_000894.1
NP_001020604.1
NP_001020605.1
NP_001273066.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011504.2 RefSeqGene

    Range
    5071..22230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000903.3NP_000894.1  NAD(P)H dehydrogenase [quinone] 1 isoform a

    See identical proteins and their annotated locations for NP_000894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AV729122, BC007659, BM052991, BM452267, BM787983, BM828301
    Consensus CDS
    CCDS10883.1
    UniProtKB/Swiss-Prot
    B2R5Y9, B4DNM7, B7ZAD1, P15559, Q86UK1
    UniProtKB/TrEMBL
    Q53G81
    Related
    ENSP00000319788.5, ENST00000320623.10
    Conserved Domains (1) summary
    pfam02525
    Location:5212
    Flavodoxin_2; Flavodoxin-like fold
  2. NM_001025433.2NP_001020604.1  NAD(P)H dehydrogenase [quinone] 1 isoform b

    See identical proteins and their annotated locations for NP_001020604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AV729122, BC000906, BC007659, BM052991, BM452267, BM787983, BM828301
    Consensus CDS
    CCDS32472.1
    UniProtKB/TrEMBL
    Q53G81
    Related
    ENSP00000368335.3, ENST00000379047.7
    Conserved Domains (1) summary
    pfam02525
    Location:5178
    Flavodoxin_2; Flavodoxin-like fold
  3. NM_001025434.2NP_001020605.1  NAD(P)H dehydrogenase [quinone] 1 isoform c

    See identical proteins and their annotated locations for NP_001020605.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AV729122, BM052991, BM787983, BM828301, CD014005
    Consensus CDS
    CCDS32471.1
    UniProtKB/TrEMBL
    Q3B792
    Related
    ENSP00000368334.2, ENST00000379046.6
    Conserved Domains (1) summary
    pfam02525
    Location:5174
    Flavodoxin_2; Flavodoxin-like fold
  4. NM_001286137.2NP_001273066.1  NAD(P)H dehydrogenase [quinone] 1 isoform d

    See identical proteins and their annotated locations for NP_001273066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform d) is shorter than isoform a.
    Source sequence(s)
    AC092115, AK297125, BQ775231
    Consensus CDS
    CCDS67067.1
    UniProtKB/TrEMBL
    B4DLR8, Q3B792
    Related
    ENSP00000398330.2, ENST00000439109.6
    Conserved Domains (1) summary
    cl00438
    Location:4101
    FMN_red; NADPH-dependent FMN reductase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    69709401..69726560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    75511583..75528719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)