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NQO1 NAD(P)H quinone dehydrogenase 1 [ Homo sapiens (human) ]

Gene ID: 1728, updated on 27-Dec-2018

Summary

Official Symbol
NQO1provided by HGNC
Official Full Name
NAD(P)H quinone dehydrogenase 1provided by HGNC
Primary source
HGNC:HGNC:2874
See related
Ensembl:ENSG00000181019 MIM:125860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTD; QR1; DHQU; DIA4; NMOR1; NMORI
Summary
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 136.7), gall bladder (RPKM 67.3) and 11 other tissues See more
Orthologs

Genomic context

See NQO1 in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (69709401..69726668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69743304..69760849, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 5 Neighboring gene small nucleolar RNA, C/D box 13H Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene non-POU domain containing, octamer-binding pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 significantly upregulates Nrf2 in human astrocytes and is associated with increased levels of key antioxidant defensive enzymes Hemoxygenase (HO-1) and NAD(P)H dehydrogenase quinone1 (Nqo1) PubMed
Rev rev HIV-1 Rev downregulates the expression of NQO1 which indirectly induces the degradation of Tat PubMed
Tat tat HIV-1 Tat upregulates NQO1, CAT, SOD1, SOD2, and HMOX1 (HO1) mRNA levels in SH-SY5Y cells PubMed
tat HIV-1 Tat is stabilized by NQO1, inhibitor of 20S poteasome PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
    Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystemResults of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA.
  • Aryl Hydrocarbon Receptor, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor, organism-specific biosystemThe Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or...
  • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
  • Benzene metabolism, organism-specific biosystem (from WikiPathways)
    Benzene metabolism, organism-specific biosystemThis pathway describes the metabolism of benzene. It is metabolised in the liver and forms several metabolites that can be toxic to the human body. Some of the metabolites are very volatile and can b...
  • Dopamine metabolism, organism-specific biosystem (from WikiPathways)
    Dopamine metabolism, organism-specific biosystem
    Dopamine metabolism
  • Estrogen metabolism, organism-specific biosystem (from WikiPathways)
    Estrogen metabolism, organism-specific biosystem
    Estrogen metabolism
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Metabolism of polyamines, organism-specific biosystem (from REACTOME)
    Metabolism of polyamines, organism-specific biosystemPolyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that ar...
  • NRF2 pathway, organism-specific biosystem (from WikiPathways)
    NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
  • Oxidative Stress, organism-specific biosystem (from WikiPathways)
    Oxidative Stress, organism-specific biosystemOxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to rep...
  • Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystemPhotodynamic therapy may induce an antioxidant response mediated by NFE2L2.
  • Regulation of ornithine decarboxylase (ODC), organism-specific biosystem (from REACTOME)
    Regulation of ornithine decarboxylase (ODC), organism-specific biosystemPolyamines increase the production of antizyme (AZ). The carboxy-terminal half of antizyme interacts with ODC, generating an inactive AZ:ODC heterodimer complex. A carboxy-terminal domain of ODC is ...
  • Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystem (from WikiPathways)
    Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystemThis pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAP...
  • Transcriptional activation by NRF2, organism-specific biosystem (from WikiPathways)
    Transcriptional activation by NRF2, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4]. Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in ox...
  • Ubiquinone and other terpenoid-quinone biosynthesis, organism-specific biosystem (from KEGG)
    Ubiquinone and other terpenoid-quinone biosynthesis, organism-specific biosystemUbiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from ...
  • Ubiquinone and other terpenoid-quinone biosynthesis, conserved biosystem (from KEGG)
    Ubiquinone and other terpenoid-quinone biosynthesis, conserved biosystemUbiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding HDA PubMed 
cytochrome-b5 reductase activity, acting on NAD(P)H TAS
Traceable Author Statement
more info
PubMed 
electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to metal ion IEA
Inferred from Electronic Annotation
more info
 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
nitric oxide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen sulfide IEA
Inferred from Electronic Annotation
more info
 
response to nitrogen compound IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission, cholinergic TAS
Traceable Author Statement
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NAD(P)H dehydrogenase [quinone] 1
Names
DT-diaphorase
NAD(P)H dehydrogenase, quinone 1
NAD(P)H:Quinone acceptor oxidoreductase type 1
NAD(P)H:menadione oxidoreductase 1
NAD(P)H:quinone oxidoreductase 1
NAD(P)H:quinone oxireductase
azoreductase
diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
diaphorase-4
dioxin-inducible 1
menadione reductase
phylloquinone reductase
quinone reductase 1
NP_000894.1
NP_001020604.1
NP_001020605.1
NP_001273066.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011504.2 RefSeqGene

    Range
    5001..22230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000903.3NP_000894.1  NAD(P)H dehydrogenase [quinone] 1 isoform a

    See identical proteins and their annotated locations for NP_000894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AV729122, BC007659, BM052991, BM452267, BM787983, BM828301
    Consensus CDS
    CCDS10883.1
    UniProtKB/Swiss-Prot
    P15559
    Related
    ENSP00000319788.5, ENST00000320623.9
    Conserved Domains (1) summary
    pfam02525
    Location:5212
    Flavodoxin_2; Flavodoxin-like fold
  2. NM_001025433.1NP_001020604.1  NAD(P)H dehydrogenase [quinone] 1 isoform b

    See identical proteins and their annotated locations for NP_001020604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AV729122, BC000906, BC007659, BM052991, BM452267, BM787983, BM828301
    Consensus CDS
    CCDS32472.1
    UniProtKB/Swiss-Prot
    P15559
    Related
    ENSP00000368335.3, ENST00000379047.7
    Conserved Domains (1) summary
    pfam02525
    Location:5178
    Flavodoxin_2; Flavodoxin-like fold
  3. NM_001025434.1NP_001020605.1  NAD(P)H dehydrogenase [quinone] 1 isoform c

    See identical proteins and their annotated locations for NP_001020605.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AV729122, BM052991, BM452267, BM787983, BM828301, CD014005
    Consensus CDS
    CCDS32471.1
    UniProtKB/Swiss-Prot
    P15559
    Related
    ENSP00000368334.2, ENST00000379046.6
    Conserved Domains (1) summary
    pfam02525
    Location:5174
    Flavodoxin_2; Flavodoxin-like fold
  4. NM_001286137.1NP_001273066.1  NAD(P)H dehydrogenase [quinone] 1 isoform d

    See identical proteins and their annotated locations for NP_001273066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform d) is shorter than isoform a.
    Source sequence(s)
    AC092115, AK297125, BQ775231, DC331440
    Consensus CDS
    CCDS67067.1
    UniProtKB/TrEMBL
    B4DLR8
    Related
    ENSP00000398330.2, ENST00000439109.6
    Conserved Domains (1) summary
    cl00438
    Location:4101
    FMN_red; NADPH-dependent FMN reductase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    69709401..69726668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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