U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Melk maternal embryonic leucine zipper kinase [ Mus musculus (house mouse) ]

Gene ID: 17279, updated on 2-Nov-2024

Summary

Official Symbol
Melkprovided by MGI
Official Full Name
maternal embryonic leucine zipper kinaseprovided by MGI
Primary source
MGI:MGI:106924
See related
Ensembl:ENSMUSG00000035683 AllianceGenome:MGI:106924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MPK38; mKIAA0175
Summary
Enables protein serine/threonine kinase activity. Involved in neural precursor cell proliferation and positive regulation of apoptotic process. Acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 14.4), placenta adult (RPKM 9.4) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Melk in Genome Data Viewer
Location:
4 B1; 4 23.46 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44300876..44364301)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44300909..44364675)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 38 Neighboring gene microRNA 5106 Neighboring gene STARR-seq mESC enhancer starr_10071 Neighboring gene STARR-seq mESC enhancer starr_10072 Neighboring gene predicted gene, 54218 Neighboring gene STARR-positive B cell enhancer ABC_E6169 Neighboring gene STARR-seq mESC enhancer starr_10073 Neighboring gene predicted gene, 24376 Neighboring gene STARR-seq mESC enhancer starr_10075 Neighboring gene STARR-seq mESC enhancer starr_10079 Neighboring gene paired box 5 Neighboring gene microRNA 5120

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neural precursor cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
maternal embryonic leucine zipper kinase
Names
protein kinase PK38
tyrosine-protein kinase MELK
NP_001405928.1
NP_001405929.1
NP_034920.2
XP_036019676.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418999.1NP_001405928.1  maternal embryonic leucine zipper kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL805952, AL807399
  2. NM_001419000.1NP_001405929.1  maternal embryonic leucine zipper kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL805952, AL807399
  3. NM_010790.3NP_034920.2  maternal embryonic leucine zipper kinase isoform 1

    See identical proteins and their annotated locations for NP_034920.2

    Status: VALIDATED

    Source sequence(s)
    AL805952, AL807399
    Consensus CDS
    CCDS18124.1
    UniProtKB/Swiss-Prot
    Q3TPU1, Q61804, Q61846, Q6ZQH6
    UniProtKB/TrEMBL
    Q3TJF3, Q3TU15
    Related
    ENSMUSP00000043806.6, ENSMUST00000045607.12
    Conserved Domains (4) summary
    cd12198
    Location:547641
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    44300876..44364301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163783.1XP_036019676.1  maternal embryonic leucine zipper kinase isoform X2

    UniProtKB/TrEMBL
    Q3TU15
    Conserved Domains (2) summary
    cd14341
    Location:281332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase