mans-1 alpha-1,2-Mannosidase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: mans-1
Gene description: alpha-1,2-Mannosidase
Primary source: WormBase:WBGene00008411
Locus tag: CELE_D2030.1
Gene type: protein coding
RNA name: alpha-1,2-Mannosidase
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

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See mans-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (7568093..7570319, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Genotypes

See SNP Geneview Report

Pathways from BioSystems

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Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
Asparagine N-linked glycosylation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
N-Glycan biosynthesis, organism-specific biosystem (from KEGG)
N-Glycan biosynthesis, organism-specific biosystemN-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glyc...
N-Glycan biosynthesis, conserved biosystem (from KEGG)
N-Glycan biosynthesis, conserved biosystemN-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glyc...
N-glycan precursor trimming, organism-specific biosystem (from KEGG)
N-glycan precursor trimming, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Glycan metabolism
N-glycan precursor trimming, conserved biosystem (from KEGG)
N-glycan precursor trimming, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Glycan metabolism
N-glycan trimming and elongation in the cis-Golgi, organism-specific biosystem (from REACTOME)
N-glycan trimming and elongation in the cis-Golgi, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2, organism-specific biosystem (from REACTOME)
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
Transport to the Golgi and subsequent modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

D2030.1 (e-PCR)
- UniSTS:307402

Homology

Homologs of the mans-1 gene: The mans-1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, rice, and frog.
Orthologs

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
catalytic activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-1,2-Mannosidase

NP_492116.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7568093..7570319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059715.5 → NP_492116.1 alpha-1,2-Mannosidase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492116.1

Status: REVIEWED

UniProtKB/TrEMBL

P90787

Conserved Domains (1) summary

pfam01532
Location:96 → 538

Glyco_hydro_47; Glycosyl hydrolase family 47