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bub-1 Mitotic checkpoint serine/threonine-protein kinase bub-1 [ Caenorhabditis elegans ]

Gene ID: 172468, updated on 5-Sep-2021

Summary

Gene symbol
bub-1
Gene description
Mitotic checkpoint serine/threonine-protein kinase bub-1
Primary source
WormBase:WBGene00000275
Locus tag
CELE_R06C7.8
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
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Genomic context

See bub-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (7251941..7255223)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Adenylosuccinate lyase Neighboring gene Protein lin-61 Neighboring gene Zinc finger putative Transcription Factor family Neighboring gene Myosin-1 Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinetochore binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic chromosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic sister chromatid cohesion, centromeric IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to kinetochore involved in kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Mitotic checkpoint serine/threonine-protein kinase bub-1
NP_492051.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7251941..7255223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059650.8NP_492051.1  Mitotic checkpoint serine/threonine-protein kinase bub-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492051.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21776
    Conserved Domains (2) summary
    cd13981
    Location:689980
    STKc_Bub1_BubR1; Catalytic domain of the Serine/Threonine kinases, Spindle assembly checkpoint proteins Bub1 and BubR1
    pfam00069
    Location:690939
    Pkinase; Protein kinase domain
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