mec-6 Mechanosensory abnormality protein 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-6
Official Full Name: Mechanosensory abnormality protein 6
Primary source: WormBase:WBGene00003170
Locus tag: CELE_W02D3.3
See related: AllianceGenome:WB:WBGene00003170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable arylesterase activity and sodium channel activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Predicted to be located in axon and plasma membrane. Is expressed in several structures, including enteric muscle; excretory cell; nerve ring; and neurons. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mec-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (6725164..6728089)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ultrasound Activation of Mechanosensory Ion Channels in Caenorhabditis Elegans.
Title: Ultrasound Activation of Mechanosensory Ion Channels in Caenorhabditis Elegans.
MEC-6 and POML-1 interact with MEC-4 to facilitate expression and localization of MEC-4 on the cell surface. Thus MEC-6 and POML-1 act more like chaperones for MEC-4 than channel components.
Title: Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.
MEC-10, but not MEC-6, forms puncta in touch receptor neurites that colocalize with MEC-4 when MEC-4 is overexpressed in the touch receptor neurons
Title: Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans.
we show that mec-6 encodes a single-pass membrane-spanning protein with limited similarity to paraoxonases; mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
Title: The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02D3.3 (e-PCR)
- UniSTS:315139

STS1-257 (e-PCR)
- UniSTS:241750

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables arylesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mechanosensory abnormality protein 6

NP_001370641.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6725164..6728089

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383275.2 → NP_001370641.1 Mechanosensory abnormality protein 6 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O01811, Q8T7S8

Conserved Domains (1) summary

pfam01731
Location:178 → 263

Arylesterase