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ech-1.2 Enoyl-CoA hydratase [ Caenorhabditis elegans ]

Gene ID: 172310, updated on 19-Jun-2024

Summary

Gene symbol
ech-1.2
Gene description
Enoyl-CoA hydratase
Locus tag
CELE_T08B2.7
See related
AllianceGenome:WB:WBGene00020347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial fatty acid beta-oxidation multienzyme complex. Is expressed in body wall musculature; hypodermis; intestine; nervous system; and tail. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ech-1.2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (6206955..6211155, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Very Early Transcript Neighboring gene BAAT_C domain-containing protein Neighboring gene Large ribosomal subunit protein uL23m Neighboring gene phenylalanine--tRNA ligase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Enoyl-CoA hydratase
NP_491789.1
  • Confirmed by transcript evidence
NP_491790.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6206955..6211155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059388.8NP_491789.1  Enoyl-CoA hydratase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491789.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GYT0
    Conserved Domains (4) summary
    cd06558
    Location:60269
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    TIGR02441
    Location:46780
    fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
    pfam00725
    Location:561656
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:381559
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
  2. NM_059389.6NP_491790.1  Enoyl-CoA hydratase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIC3
    Conserved Domains (4) summary
    cd06558
    Location:34243
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    TIGR02441
    Location:20754
    fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
    pfam00725
    Location:535630
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:355533
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain