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Cma1 chymase 1, mast cell [ Mus musculus (house mouse) ]

Gene ID: 17228, updated on 23-May-2018
Official Symbol
Cma1provided by MGI
Official Full Name
chymase 1, mast cellprovided by MGI
Primary source
MGI:MGI:96941
See related
Ensembl:ENSMUSG00000022225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcp5; Mcp-5; Mcpt5; MMCP-5
Summary
This gene encodes a serine protease that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. The encoded preproprotein undergoes proteolytic processing to generate a functional enzyme with elastase-like activity. Mice lacking the encoded protein exhibit significant attenuation of ischemia-reperfusion injury of the skeletal muscle. This gene is located in a cluster of related mast cell protease genes on chromosome 14. [provided by RefSeq, Nov 2015]
Expression
Biased expression in limb E14.5 (RPKM 20.7), mammary gland adult (RPKM 10.9) and 4 other tissues See more
Orthologs
See Cma1 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (55941451..55944675, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56560288..56563498, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cerebellin 3 precursor protein Neighboring gene KH and NYN domain containing Neighboring gene short chain dehydrogenase/reductase family 39U, member 1 Neighboring gene mast cell protease, pseudogene 1 Neighboring gene chymase 2, mast cell Neighboring gene ubiquitin-conjugating enzyme E2, J2 homolog pseudogene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
basement membrane disassembly ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 beta biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
chymase
Names
alpha-chymase
mast cell chymase 1
mast cell protease 5
mast cell protease I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010780.3NP_034910.2  chymase preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC163646, BC139457
    Consensus CDS
    CCDS27135.1
    Related
    ENSMUSP00000022834.6, ENSMUST00000022834.6
    Conserved Domains (1) summary
    cd00190
    Location:22243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    55941451..55944675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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