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pgp-2 P-GlycoProtein related [ Caenorhabditis elegans ]

Gene ID: 172262, updated on 8-Mar-2025

Summary

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Official Symbol
pgp-2
Official Full Name
P-GlycoProtein related
Primary source
WormBase:WBGene00003996
Locus tag
CELE_C34G6.4
See related
AllianceGenome:WB:WBGene00003996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in gut granule assembly and lipid storage. Located in gut granule membrane. Is expressed in intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cholestasis (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Mar 2025]
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Genomic context

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See pgp-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (5886613..5895973)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Non-histone chromosomal protein HMG-14 Neighboring gene ShKT domain-containing protein Neighboring gene Signal transducing adapter molecule 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ABC transporter PGP-2 from Caenorhabditis elegans is expressed in the sensory neuron pair AWA and contributes to lysosome formation and lipid storage within the intestine. Nunes F, et al. Biochem Biophys Res Commun, 2005 Dec 16. PMID 16243293
  2. The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans. Chun H, et al. J Biol Chem, 2017 Jan 6. PMID 27881675, Free PMC Article
  3. Lysosome-related organelles promote stress and immune responses in C. elegans. Hajdú G, et al. Commun Biol, 2023 Sep 13. PMID 37704756, Free PMC Article
  4. The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. Lincke CR, et al. J Mol Biol, 1992 Nov 20. PMID 1360540
  5. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. Broeks A, et al. EMBO J, 1995 May 1. PMID 7743993, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results provide an explanation for the loss of Nile Red-stained fat in pgp-2(-) animals as well as insight into the specialized function of this lysosome-related organelle.
    Title: Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in gut granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in gut granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P-GlycoProtein related
NP_001300410.1
  • Product from WormBase gene class pgp;
    Confirmed by transcript evidence
NP_001300411.1
  • Product from WormBase gene class pgp;
    Confirmed by transcript evidence
NP_001300412.1
  • Product from WormBase gene class pgp;
    Confirmed by transcript evidence
NP_491707.2
  • Product from WormBase gene class pgp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5886613..5895973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059306.7 → NP_491707.2  P-GlycoProtein related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491707.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDF9
    Conserved Domains (3) summary
    cd03249
    Location:399 → 632
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:56 → 1262
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:61 → 349
    ABC_membrane; ABC transporter transmembrane region

  2. NM_001313481.3 → NP_001300410.1  P-GlycoProtein related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQN5
    Conserved Domains (3) summary
    cd03249
    Location:399 → 632
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:56 → 1286
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:61 → 349
    ABC_membrane; ABC transporter transmembrane region

  3. NM_001313483.4 → NP_001300412.1  P-GlycoProtein related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWK1
    Conserved Domains (3) summary
    cd03249
    Location:392 → 625
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:49 → 1255
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:54 → 342
    ABC_membrane; ABC transporter transmembrane region

  4. NM_001313482.3 → NP_001300411.1  P-GlycoProtein related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU66
    Conserved Domains (3) summary
    cd03249
    Location:392 → 625
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:49 → 1279
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:54 → 342
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
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