U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pgp-2 ABC-type xenobiotic transporter [ Caenorhabditis elegans ]

Gene ID: 172262, updated on 6-Jul-2026
Official Symbol
pgp-2
Official Full Name
ABC-type xenobiotic transporter
Primary source
WormBase:WBGene00003996
Locus tag
CELE_C34G6.4
See related
AllianceGenome:WB:WBGene00003996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in gut granule assembly and lipid storage. Located in gut granule membrane. Is expressed in intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cholestasis (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1) and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Jul 2025]
Try the new Gene page
Try the new Transcripts and proteins table
See pgp-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (5886613..5895973)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Non-histone chromosomal protein HMG-14 Neighboring gene ShKT domain-containing protein Neighboring gene Signal transducing adapter molecule 1

Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The ABC transporter PGP-2 from Caenorhabditis elegans is expressed in the sensory neuron pair AWA and contributes to lysosome formation and lipid storage within the intestine. Nunes F, et al. Biochem Biophys Res Commun, 2005 Dec 16. PMID 16243293
  2. The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans. Chun H, et al. J Biol Chem, 2017 Jan 6. PMID 27881675, Free PMC Article
  3. Lysosome-related organelles promote stress and immune responses in C. elegans. Hajdú G, et al. Commun Biol, 2023 Sep 13. PMID 37704756, Free PMC Article
  4. The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. Lincke CR, et al. J Mol Biol, 1992 Nov 20. PMID 1360540
  5. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. Broeks A, et al. EMBO J, 1995 May 1. PMID 7743993, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results provide an explanation for the loss of Nile Red-stained fat in pgp-2(-) animals as well as insight into the specialized function of this lysosome-related organelle.
    Title: Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ABC-type xenobiotic transporter
NP_001300410.1
  • Confirmed by transcript evidence
NP_001300411.1
  • Confirmed by transcript evidence
NP_001300412.1
  • Confirmed by transcript evidence
NP_491707.2
  • Confirmed by transcript evidence

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5886613..5895973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059306.7 → NP_491707.2  ABC-type xenobiotic transporter

    See identical proteins and their annotated locations for NP_491707.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDF9, G5EDG0
    Conserved Domains (3) summary
    cd03249
    Location:399 → 632
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:56 → 1262
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:61 → 349
    ABC_membrane; ABC transporter transmembrane region

  2. NM_001313481.3 → NP_001300410.1  ABC-type xenobiotic transporter

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AQN5
    Conserved Domains (3) summary
    cd03249
    Location:399 → 632
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:56 → 1286
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:61 → 349
    ABC_membrane; ABC transporter transmembrane region

  3. NM_001313483.4 → NP_001300412.1  ABC-type xenobiotic transporter

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWK1
    Conserved Domains (3) summary
    cd03249
    Location:392 → 625
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:49 → 1255
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:54 → 342
    ABC_membrane; ABC transporter transmembrane region

  4. NM_001313482.3 → NP_001300411.1  ABC-type xenobiotic transporter

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU66
    Conserved Domains (3) summary
    cd03249
    Location:392 → 625
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:49 → 1279
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:54 → 342
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools