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atp-3 ATP synthase subunit O, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 172195, updated on 3-May-2025
Official Symbol
atp-3
Official Full Name
ATP synthase subunit O, mitochondrial
Primary source
WormBase:WBGene00000230
Locus tag
CELE_F27C1.7
See related
AllianceGenome:WB:WBGene00000230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in determination of adult lifespan and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial inner membrane. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 7. Orthologous to human ATP5PO (ATP synthase peripheral stalk subunit OSCP). [provided by Alliance of Genome Resources, May 2025]
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See atp-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (5428545..5429819, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small-subunit processome Neighboring gene uncharacterized protein Neighboring gene Dauer Up-Regulated Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Copper transport protein

Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Bridging the phenotypic gap: real-time assessment of mitochondrial function and metabolism of the nematode Caenorhabditis elegans. Lagido C, et al. BMC Physiol, 2008 Apr 2. PMID 18384668, Free PMC Article
  2. Monitoring newly synthesized proteins over the adult life span of Caenorhabditis elegans. Vukoti K, et al. J Proteome Res, 2015 Mar 6. PMID 25686393, Free PMC Article
  3. Expression of a FRET-based ATP Biosensor in the C. elegans Intestine. Soto J, et al. MicroPubl Biol, 2020 Jul 30. PMID 32760881, Free PMC Article
  4. Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase. Qi B, et al. Cell, 2018 Oct 4. PMID 30146159
  5. ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans. Kawasaki I, et al. Mech Dev, 2007 Mar. PMID 17223323

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ATP synthase subunit O, mitochondrial
NP_001021421.1
  • Confirmed by transcript evidence
NP_001370527.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5428545..5429819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383096.2 → NP_001370527.1  ATP synthase subunit O, mitochondrial [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91283
    Conserved Domains (1) summary
    pfam00213
    Location:30 → 203
    OSCP; ATP synthase delta (OSCP) subunit

  2. NM_001026250.7 → NP_001021421.1  ATP synthase subunit O, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021421.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNG1
    Conserved Domains (1) summary
    pfam00213
    Location:51 → 224
    OSCP; ATP synthase delta (OSCP) subunit
Nucleotide Protein
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